Higher frequency of thyroid dysfunction in type 2 diabetes mellitus is independent of deranged lipid profile in streptozotocin induced diabetic Sprague Dawley rats

Sidra Arshad; Mahvash Khan; Hira Ayaz; Anjum Syed; Ghazala Jawwad; Nasar Abbas Shamsi

Abstract
Objective: To explore the role of dyslipidemia in development of thyroid disorder in type two diabetes mellitus.
Methodology: In this randomized control trial, 60 Sprague Dawley rats were divided into two groups with 30 rats in each group. Group 1 (control group) was fed on normal pellet diet and water whereas group two (diabetic group) was fed high fat diet to produce insulin resistance. After 2 weeks, an intra-peritoneal injection of normal saline was given to all the rats in-group 1, and group 2 rats were given single intra-peritoneal injection of Streptozocin (35 mg/kg) to produce hyperglycemia. At the end of study period (8 weeks), serum lipid profile, triiodothyronine, thyroxine and thyroid stimulating hormone levels were measured. Pearson correlation coefficient was calculated to find correlation between lipid profile and thyroid profile.
Results: There was no significant correlation of thyroid stimulating hormone, triiodothyronine and thyroxine with the parameters of lipid profile.
Conclusion: The deranged lipid profile had no role in disturbing the thyroid hormone levels in STZ induced type 2 diabetic Sprague Dawley rats.

Key words: Type 2 diabetes mellitus, thyroid dysfunctions, dyslipidemia.

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