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Original Research 
RMJ. 2021; 46(4): 799-802


Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults

Haji Muahammad Rashid, Sumbla Ghaznavi, Nadia Awan.

Abstract
Objective: To compare Absolute eosinophil count (AEC), IgE and Eosinophil derived neurotoxin (EDN) between severe persistent asthmatic and non-asthmatic adults and to find the correlation of EDN with AEC and Forced Expiratory Volume (FEV) in severe persistent asthmatic patients.
Methodology: This cross sectional study was carried out at the Department of Chemical Pathology, University of Health Sciences Lahore, Pakistan. Pre diagnosed 32 severe persistent asthmatic patients and 32 ages and gender matched non-asthmatic adults were enrolled in the study. Their lung function data and blood samples for the assessment of AEC, IgE and EDN were collected. Pair wise comparisons between two groups were performed by Mann-Whitney U test.
Results: AEC in severe persistent asthmatic patients (546±411 /ul) was significantly higher than non-asthmatic adults (125±64/ul). Serum IgE (845.3±334.3 IU/L) and EDN (34881±12321ng/ml) were also high in severe persistent asthmatic patients than non-asthmatic adults (p<0.00001). We found a strong negative association between FEV1 and EDN (-0.755) and strong positive relationship between AEC and EDN (0.901).
Conclusion: Serum EDN levels were high in SPA along with high levels of serum IgE and AEC. Serum EDN had a significant negative correlation with FEV1 and positive correlation with AEC in severe persistent asthmatic patients.

Key words: Asthma, spirometry, eosinophil, eosinophil derived neurotoxin, immunoglobulin E, severe persistent asthma.


 
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How to Cite this Article
Pubmed Style

Rashid HM, Ghaznavi S, Awan N. Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. RMJ. 2021; 46(4): 799-802.

Web Style

Rashid HM, Ghaznavi S, Awan N. Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. https://www.rmj.org.pk/?mno=55307 [Access: December 05, 2023].

AMA (American Medical Association) Style

Rashid HM, Ghaznavi S, Awan N. Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. RMJ. 2021; 46(4): 799-802.


Vancouver/ICMJE Style

Rashid HM, Ghaznavi S, Awan N. Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. RMJ. (2021), [cited December 05, 2023]; 46(4): 799-802.


Harvard Style

Rashid, H. M., Ghaznavi, . S. & Awan, . N. (2021) Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. RMJ, 46 (4), 799-802.


Turabian Style

Rashid, Haji Muahammad, Sumbla Ghaznavi, and Nadia Awan. 2021. Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. Rawal Medical Journal, 46 (4), 799-802.


Chicago Style

Rashid, Haji Muahammad, Sumbla Ghaznavi, and Nadia Awan. "Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults." Rawal Medical Journal 46 (2021), 799-802.


MLA (The Modern Language Association) Style

Rashid, Haji Muahammad, Sumbla Ghaznavi, and Nadia Awan. "Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults." Rawal Medical Journal 46.4 (2021), 799-802. Print.


APA (American Psychological Association) Style

Rashid, H. M., Ghaznavi, . S. & Awan, . N. (2021) Comparison of eosinophil derived neurotoxin, immunoglobulin E and absolute eosinophil count in severe persistent asthmatic and non-asthmatic adults. Rawal Medical Journal, 46 (4), 799-802.


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