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Original Research 
RMJ. 2023; 48(2): 522-525


Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity

Salma Salim, Uzma Naeem, Farzana Munir, Fatima Muhammad Barki, Mahreen Mirza, Mushayada Irshad.

Abstract
Objective: To compare the cardioprotective effects of Nigella sativa and Enalapril in Doxorubicin-induced cardiotoxicity in rats.
Methodology: This experimental randomized control trial was conducted in Department of Pharmacology, International Islamic Medical College in alliance with the Riphah Institute of Pharmaceutical Sciences, and the National Institute of Health, Islamabad, Pakistan from September 20210 to August 2021. Forty adult male rats were divided into four groups each having ten rats. The normal control (group-1) received no medication throughout the experiment, while on day eight, cardiotoxicity was induced in Groups 2, 3, and 4 by a cumulative intraperitoneal dose of Doxorubicin 15mg/kg. After the confirmation of cardiotoxicity, group 3 rats received Nigella sativa 100mg/kg/day, and group 4 received enalapril 2mg/kg orally for 14 days. On day zero, baseline blood samples were taken and normal values of Trop T, Trop I, and CKMB were recorded for comparisons. Second samples were taken on day eleven to confirm cardiotoxicity, and final sampling was done on day 24, through cardiac puncture. Data were analyzed through SPSS 22. Comparisons among the groups were done through one-way ANOVA and paired t-tests and a p<0.05 was deemed analytically meaningful.
Results: Enalapril produced a more significant reduction in Trop T, Trop I, and CK-MB levels as compared to Nigella sativa (p<0.05).

Key words: Doxorubicin, cardiotoxicity, enalapril, Nigella sativa.


 
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How to Cite this Article
Pubmed Style

Salim S, Naeem U, Munir F, Barki FM, Mirza M, Irshad M. Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. RMJ. 2023; 48(2): 522-525.

Web Style

Salim S, Naeem U, Munir F, Barki FM, Mirza M, Irshad M. Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. https://www.rmj.org.pk/?mno=107111 [Access: December 05, 2023].

AMA (American Medical Association) Style

Salim S, Naeem U, Munir F, Barki FM, Mirza M, Irshad M. Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. RMJ. 2023; 48(2): 522-525.


Vancouver/ICMJE Style

Salim S, Naeem U, Munir F, Barki FM, Mirza M, Irshad M. Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. RMJ. (2023), [cited December 05, 2023]; 48(2): 522-525.


Harvard Style

Salim, S., Naeem, . U., Munir, . F., Barki, . F. M., Mirza, . M. & Irshad, . M. (2023) Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. RMJ, 48 (2), 522-525.


Turabian Style

Salim, Salma, Uzma Naeem, Farzana Munir, Fatima Muhammad Barki, Mahreen Mirza, and Mushayada Irshad. 2023. Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. Rawal Medical Journal, 48 (2), 522-525.


Chicago Style

Salim, Salma, Uzma Naeem, Farzana Munir, Fatima Muhammad Barki, Mahreen Mirza, and Mushayada Irshad. "Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity." Rawal Medical Journal 48 (2023), 522-525.


MLA (The Modern Language Association) Style

Salim, Salma, Uzma Naeem, Farzana Munir, Fatima Muhammad Barki, Mahreen Mirza, and Mushayada Irshad. "Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity." Rawal Medical Journal 48.2 (2023), 522-525. Print.


APA (American Psychological Association) Style

Salim, S., Naeem, . U., Munir, . F., Barki, . F. M., Mirza, . M. & Irshad, . M. (2023) Comparative effects of Nigella sativa and enalapril in doxorubicin induce cardiotoxicity. Rawal Medical Journal, 48 (2), 522-525.


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