ISSN 0303-5212
 

Original Research 
RMJ. 2022; 47(3): 585-588


The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan

Saeedunisa Sangi, Shabnum Naz Shaikh, Ahmed Bux Shaikh, Sumera Brohi, Shazia Shaikh, Shaista Hifaz Abro.

Abstract
Objective: To compare effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy.
Methodology: This randomized controlled trial was conducted at Chandka Medical College Larkana from May 2018 to May 2020. The enrollment criteria included all women between the ages of 18 and 45 years; symptomatic patients with Visual Analog Scale (VAS) scores >3 points; diagnosed with focal or diffuse adenomyosis; and post-operative histopathological confirmation of adenomyosis. We divided 150 patients in three groups having 50 patients in each group. In-group A GnRH was given, in-group B LNG-IUS was given and in Group C, no pharmacological treatment given postoperatively. All patients had regular three follow-up at two weekly intervals and VAS pain scores were recorded postoperatively and at each follow-up visit.
Results: VAS scores of all patients decreased from 7.0 (0.6) to 4 (0.3) at the 6 months, postoperatively. The postoperative VAS was significantly higher in-group C (no medical treatment) compared to group A and B, (p<0.05). Dysmenorrhea was noted in 24 (48.00%), 23 (46.00%), and 17 (34.00%) in Group A, B, and C, respectively which was significantly higher in group C.
Conclusion: The current study highlighted the significance of medical treatment with GnRH and LNG-IUS treatment following adenomyomectomy and recommend all patients be administered this to produce better patient outcome.

Key words: Adenomyosis, GnRH, LNG-IUS and Post adenomyomectomy.


 
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How to Cite this Article
Pubmed Style

Sangi S, Shaikh SN, Shaikh AB, Brohi S, Shaikh S, Abro SH. The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. RMJ. 2022; 47(3): 585-588.


Web Style

Sangi S, Shaikh SN, Shaikh AB, Brohi S, Shaikh S, Abro SH. The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. https://www.rmj.org.pk/?mno=124870 [Access: December 07, 2023].


AMA (American Medical Association) Style

Sangi S, Shaikh SN, Shaikh AB, Brohi S, Shaikh S, Abro SH. The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. RMJ. 2022; 47(3): 585-588.



Vancouver/ICMJE Style

Sangi S, Shaikh SN, Shaikh AB, Brohi S, Shaikh S, Abro SH. The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. RMJ. (2022), [cited December 07, 2023]; 47(3): 585-588.



Harvard Style

Sangi, S., Shaikh, . S. N., Shaikh, . A. B., Brohi, . S., Shaikh, . S. & Abro, . S. H. (2022) The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. RMJ, 47 (3), 585-588.



Turabian Style

Sangi, Saeedunisa, Shabnum Naz Shaikh, Ahmed Bux Shaikh, Sumera Brohi, Shazia Shaikh, and Shaista Hifaz Abro. 2022. The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. Rawal Medical Journal, 47 (3), 585-588.



Chicago Style

Sangi, Saeedunisa, Shabnum Naz Shaikh, Ahmed Bux Shaikh, Sumera Brohi, Shazia Shaikh, and Shaista Hifaz Abro. "The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan." Rawal Medical Journal 47 (2022), 585-588.



MLA (The Modern Language Association) Style

Sangi, Saeedunisa, Shabnum Naz Shaikh, Ahmed Bux Shaikh, Sumera Brohi, Shazia Shaikh, and Shaista Hifaz Abro. "The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan." Rawal Medical Journal 47.3 (2022), 585-588. Print.



APA (American Psychological Association) Style

Sangi, S., Shaikh, . S. N., Shaikh, . A. B., Brohi, . S., Shaikh, . S. & Abro, . S. H. (2022) The effectiveness of pharmacological treatment for adenomyosis with GnRH and LNG-IUS post adenomyomectomy at Shaikh Zaid Woman Hospital Larkana Pakistan. Rawal Medical Journal, 47 (3), 585-588.