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Original Research 


Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism

Muhammad Shakil, Kaukab Sultana, Rana Naveed Iqbal, Muhammad Ikram Ullah, Shabbir Hussain, Saqib Mahmood.

Abstract
Objective: To determine the serum levels of melanin, α-MSH, and to find their association and correlation in patients with Oculocutaneous albinism (OCA).
Methodology: This study included 80 subjects; 40 OCA patients and 40 healthy controls. ELISA was performed to determine the serum concentrations of melanin and α-MSH.
Results: Serum melanin level of 6.0 ng/dL was significantly reduced and serum levels of α-MSH of 9.8 ng/dL was significantly higher (p<0.05) in patients as compared to healthy controls who had 14 and 3.48, respectively.
Conclusion: serum melanin levels were found low with a compensatory rise in α-MSH levels in OCA patients as compared to controls.

Key words: Oculocutaneous albinism (OCA), melanin, alpha-melanocyte stimulating hormone (α-MSH), Pakistan.


 
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How to Cite this Article
Pubmed Style

Shakil M, Sultana K, Iqbal RN, Ullah MI, Hussain S, Mahmood S. Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. RMJ. 2022; 47(1): 30-33.

Web Style

Shakil M, Sultana K, Iqbal RN, Ullah MI, Hussain S, Mahmood S. Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. https://www.rmj.org.pk/?mno=51959 [Access: December 08, 2023].

AMA (American Medical Association) Style

Shakil M, Sultana K, Iqbal RN, Ullah MI, Hussain S, Mahmood S. Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. RMJ. 2022; 47(1): 30-33.


Vancouver/ICMJE Style

Shakil M, Sultana K, Iqbal RN, Ullah MI, Hussain S, Mahmood S. Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. RMJ. (2022), [cited December 08, 2023]; 47(1): 30-33.


Harvard Style

Shakil, M., Sultana, . K., Iqbal, . R. N., Ullah, . M. I., Hussain, . S. & Mahmood, . S. (2022) Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. RMJ, 47 (1), 30-33.


Turabian Style

Shakil, Muhammad, Kaukab Sultana, Rana Naveed Iqbal, Muhammad Ikram Ullah, Shabbir Hussain, and Saqib Mahmood. 2022. Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. Rawal Medical Journal, 47 (1), 30-33.


Chicago Style

Shakil, Muhammad, Kaukab Sultana, Rana Naveed Iqbal, Muhammad Ikram Ullah, Shabbir Hussain, and Saqib Mahmood. "Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism." Rawal Medical Journal 47 (2022), 30-33.


MLA (The Modern Language Association) Style

Shakil, Muhammad, Kaukab Sultana, Rana Naveed Iqbal, Muhammad Ikram Ullah, Shabbir Hussain, and Saqib Mahmood. "Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism." Rawal Medical Journal 47.1 (2022), 30-33. Print.


APA (American Psychological Association) Style

Shakil, M., Sultana, . K., Iqbal, . R. N., Ullah, . M. I., Hussain, . S. & Mahmood, . S. (2022) Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism. Rawal Medical Journal, 47 (1), 30-33.


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