ISSN 0303-5212
 
2024, Vol: 49, Issue: 1
49 / 1Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_ Certificate.docx
Bank Reciept

Original Research 
RMJ. 2023; 48(1): 265-268


Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice

Farah Deeba, Shehla Khatoon, Ronaq Zaman, Fatima Daud, Sadia Shaukat, Tahira Mehreen.

Abstract
Objective: To observe the protective effects of turmeric against methotrexate induced hepatotoxicity.
Methodology: This experimental study included 28 adult male albino mice which were divided into control Group A and experimental Groups, B, C and D. In control Group A, 4 mice, and in Group B, C and D 8 mice were included. To group A, no drug was given. Turmeric extract per oral (400mg /kg) daily was given to Group B for 14 days. Injection methotrexate (40mg/kg) intraperitoneal (I.P) was given to Group C on day 7. Turmeric extract per oral (400mg /kg) daily for 7 days was given to Group D as pre administration to injection methotrexate and on day 7 injection methotrexate (40mg/kg) was given intraperitoneally (I.P) and turmeric extract per oral (400mg/kg) was given for further 7 days daily, post administration to injection methotrexate. All the animals were dissected on day 14 and liver was examined under light microscope to study histological parameters.
Results: The histological examination of liver sections of group A (control) showed normal appearance of portal vein. In Group B (turmeric treated group), no obvious histological changes were observed. Examination of liver tissue of Group C (methotrexate group) showed severe histological changes, which included congestion of portal vein. Group D (methotrexate +turmeric group) showed significant reduction in congestion of portal vein.
Conclusion: This study clearly demonstrates that administration of turmeric (Curcuma Longa) protects liver tissue.

Key words: Turmeric, methotrexate, liver damage, congestion in portal vein, antioxidant.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Farah Deeba
Articles by Shehla Khatoon
Articles by Ronaq Zaman
Articles by Fatima Daud
Articles by Sadia Shaukat
Articles by Tahira Mehreen
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Deeba F, Khatoon S, Zaman R, Daud F, Shaukat S, Mehreen T. Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. RMJ. 2023; 48(1): 265-268.

Web Style

Deeba F, Khatoon S, Zaman R, Daud F, Shaukat S, Mehreen T. Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. https://www.rmj.org.pk/?mno=54516 [Access: December 08, 2023].

AMA (American Medical Association) Style

Deeba F, Khatoon S, Zaman R, Daud F, Shaukat S, Mehreen T. Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. RMJ. 2023; 48(1): 265-268.


Vancouver/ICMJE Style

Deeba F, Khatoon S, Zaman R, Daud F, Shaukat S, Mehreen T. Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. RMJ. (2023), [cited December 08, 2023]; 48(1): 265-268.


Harvard Style

Deeba, F., Khatoon, . S., Zaman, . R., Daud, . F., Shaukat, . S. & Mehreen, . T. (2023) Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. RMJ, 48 (1), 265-268.


Turabian Style

Deeba, Farah, Shehla Khatoon, Ronaq Zaman, Fatima Daud, Sadia Shaukat, and Tahira Mehreen. 2023. Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. Rawal Medical Journal, 48 (1), 265-268.


Chicago Style

Deeba, Farah, Shehla Khatoon, Ronaq Zaman, Fatima Daud, Sadia Shaukat, and Tahira Mehreen. "Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice." Rawal Medical Journal 48 (2023), 265-268.


MLA (The Modern Language Association) Style

Deeba, Farah, Shehla Khatoon, Ronaq Zaman, Fatima Daud, Sadia Shaukat, and Tahira Mehreen. "Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice." Rawal Medical Journal 48.1 (2023), 265-268. Print.


APA (American Psychological Association) Style

Deeba, F., Khatoon, . S., Zaman, . R., Daud, . F., Shaukat, . S. & Mehreen, . T. (2023) Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice. Rawal Medical Journal, 48 (1), 265-268.


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information