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Original Research 


Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia

Prastiya Indra Gunawan, Kartika Hardiyani, I Dewa Gede Ugrasena.

Abstract
Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool.
Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The inclusion criteria were Acute Lymphoblastic Leukemia (ALL) children aged 4-18 years that had undergone chemotherapy treatment, received a cumulative dose of vincristine >12 mg/m2, had no muscle weakness and signed informed consent. The TNS-PV instrument were used to assess VIPN and nerve conduction studies (NCS) was used as the gold standard.
Results: A total of 54 children were enrolled, two refused to sign the informed consent. About 60% were male children, 76.9% aged <10 years old, and 94% were ALL-L1. The TNS-PV had an area under the curve (AUC) of 0.638 (95% CI 0.531-0.834) with cut off value of 3.5. It had a sensitivity 87.9%; specificity 42.1%, positive predictive value 72.5%; negative predictive value (NPV) 66.6% and OR (Odds ratio) 5,273.
Conclusion: TNS-PV score cannot replace NCS as the gold standard, but TNS-PV can be an alternative tool for diagnosing VIPN.

Key words: Acute Lymphoblastic Leukemia, total neuropathy scale pediatric visncristine, vincristine induced peripheral neuropathy.


 
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How to Cite this Article
Pubmed Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. 2023; 48(1): 179-184. doi:10.5455/rmj20220613092311

Web Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. https://www.rmj.org.pk/?mno=57032 [Access: December 06, 2023]. doi:10.5455/rmj20220613092311

AMA (American Medical Association) Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. 2023; 48(1): 179-184. doi:10.5455/rmj20220613092311


Vancouver/ICMJE Style

Gunawan PI, Hardiyani K, Ugrasena IDG. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ. (2023), [cited December 06, 2023]; 48(1): 179-184. doi:10.5455/rmj20220613092311


Harvard Style

Gunawan, P. I., Hardiyani, . K. & Ugrasena, . I. D. G. (2023) Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. RMJ, 48 (1), 179-184. doi:10.5455/rmj20220613092311


Turabian Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. 2023. Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. Rawal Medical Journal, 48 (1), 179-184. doi:10.5455/rmj20220613092311


Chicago Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. "Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia." Rawal Medical Journal 48 (2023), 179-184. doi:10.5455/rmj20220613092311


MLA (The Modern Language Association) Style

Gunawan, Prastiya Indra, Kartika Hardiyani, and I Dewa Gede Ugrasena. "Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia." Rawal Medical Journal 48.1 (2023), 179-184. Print. doi:10.5455/rmj20220613092311


APA (American Psychological Association) Style

Gunawan, P. I., Hardiyani, . K. & Ugrasena, . I. D. G. (2023) Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia. Rawal Medical Journal, 48 (1), 179-184. doi:10.5455/rmj20220613092311


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