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Original Research 


Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes

Nausheen Ata, Zainab Rahman, Mehwish Gilani, Noaman Ishaq, Muhammad Wasiullah Khan, Qurra tul ain Haider.

Abstract
Objective: To ascertain the outcome of vitamin D3 supplementation on blood sugar fasting (BSF) of individuals with pre-diabetes and co-existing hypovitaminosis D3.
Methodology: This quasi experimental study was carried out in the Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi from January to December 2019. Non probability convenience sampling was done, and 140 individuals with pre-diabetes (BSF: 5.7-6.9 mmol/L) and co-existing hypovitaminosis D3 (<50 nmol/L) were included in the study. Age was between 21 to 60 years of either gender. They were randomly selected to receive 200,000 IU of cholecalciferol (vitamin D3 n=70) or placebo (n=70), in one dose at the commencement of study, and after one month. The outcome between BSF and vitamin D3 were compared and analysed after 12 weeks by SPSS version 23.
Results: The median of blood sugar fasting in the vitamin D3 group decreased from 5.4 to 5.1 and the interquartile range (IQR) decreased from 5.7-5.1 to 5.6-5.0 versus placebo (p=0.001). Thus, there was a significant reduction in BSF in vit D3 group versus placebo.
Conclusion: Vitamin D3 supplementation in individuals with pre-diabetes and co-existing hypovitaminosis D3 resulted in decrease in BSF and thus lowered the risk of progression to type 2 diabetes mellitus.

Key words: Cholecalciferol, hypovitaminosis, pre-diabetes, supplementation, treatment.


 
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How to Cite this Article
Pubmed Style

Ata N, Rahman Z, Gilani M, Ishaq N, Khan MW, Haider Qta. Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. RMJ. 2022; 47(1): 18-21.

Web Style

Ata N, Rahman Z, Gilani M, Ishaq N, Khan MW, Haider Qta. Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. https://www.rmj.org.pk/?mno=95666 [Access: December 06, 2023].

AMA (American Medical Association) Style

Ata N, Rahman Z, Gilani M, Ishaq N, Khan MW, Haider Qta. Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. RMJ. 2022; 47(1): 18-21.


Vancouver/ICMJE Style

Ata N, Rahman Z, Gilani M, Ishaq N, Khan MW, Haider Qta. Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. RMJ. (2022), [cited December 06, 2023]; 47(1): 18-21.


Harvard Style

Ata, N., Rahman, . Z., Gilani, . M., Ishaq, . N., Khan, . M. W. & Haider, . Q. t. a. (2022) Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. RMJ, 47 (1), 18-21.


Turabian Style

Ata, Nausheen, Zainab Rahman, Mehwish Gilani, Noaman Ishaq, Muhammad Wasiullah Khan, and Qurra tul ain Haider. 2022. Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. Rawal Medical Journal, 47 (1), 18-21.


Chicago Style

Ata, Nausheen, Zainab Rahman, Mehwish Gilani, Noaman Ishaq, Muhammad Wasiullah Khan, and Qurra tul ain Haider. "Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes." Rawal Medical Journal 47 (2022), 18-21.


MLA (The Modern Language Association) Style

Ata, Nausheen, Zainab Rahman, Mehwish Gilani, Noaman Ishaq, Muhammad Wasiullah Khan, and Qurra tul ain Haider. "Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes." Rawal Medical Journal 47.1 (2022), 18-21. Print.


APA (American Psychological Association) Style

Ata, N., Rahman, . Z., Gilani, . M., Ishaq, . N., Khan, . M. W. & Haider, . Q. t. a. (2022) Response of blood sugar fasting to vitamin D3 in individuals with pre-diabetes. Rawal Medical Journal, 47 (1), 18-21.


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