ISSN 0303-5212
 

Original Research 
RMJ. 2026; 51(2): 552-556


Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery

Arif Malik, Anoosh Qayyum, Jehanzaib Islam, Gul Zaib, Haleema Saadia, Ayesha Zahid.


Abstract
Objective: To assess the ability of anti-inflammatory phytochemicals to suppress IL-6 production and restore T cell homeostasis.
Methodology: We tested 15 phytocompounds protein-ligand docked and the best three were chosen for study. Swiss modeling employed homology modeling to predict 3D structure and ITASSER for cross validation.
Result: Wedelolactone, Catechin, and Quercetin interact strongly with the targeted protein IL-6 in In-Silico molecular docking experiments. All top 3 phytocompounds predicted IL-6 active sites with low binding energies and strong affinity (-7.3 to -7.8 kcal/mol). Phytocompounds' drug-likeness, ADMET profiles, and toxicity predictions were promising.
Conclusion: IL-6 projected structure is trustworthy for corona virus structural and functional research. The anticipated binding locations may help build new corona virus-fighting drugs.

Key words: COVID-19, interleukin-6, molecular docking, SwissADME, ProTox-3.0.


 
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How to Cite this Article
Pubmed Style

Malik A, Qayyum A, Islam J, Zaib G, Saadia H, Zahid A. Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. RMJ. 2026; 51(2): 552-556.


Web Style

Malik A, Qayyum A, Islam J, Zaib G, Saadia H, Zahid A. Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. https://www.rmj.org.pk/?mno=221813 [Access: May 27, 2026].


AMA (American Medical Association) Style

Malik A, Qayyum A, Islam J, Zaib G, Saadia H, Zahid A. Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. RMJ. 2026; 51(2): 552-556.



Vancouver/ICMJE Style

Malik A, Qayyum A, Islam J, Zaib G, Saadia H, Zahid A. Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. RMJ. (2026), [cited May 27, 2026]; 51(2): 552-556.



Harvard Style

Malik, A., Qayyum, . A., Islam, . J., Zaib, . G., Saadia, . H. & Zahid, . A. (2026) Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. RMJ, 51 (2), 552-556.



Turabian Style

Malik, Arif, Anoosh Qayyum, Jehanzaib Islam, Gul Zaib, Haleema Saadia, and Ayesha Zahid. 2026. Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. Rawal Medical Journal, 51 (2), 552-556.



Chicago Style

Malik, Arif, Anoosh Qayyum, Jehanzaib Islam, Gul Zaib, Haleema Saadia, and Ayesha Zahid. "Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery." Rawal Medical Journal 51 (2026), 552-556.



MLA (The Modern Language Association) Style

Malik, Arif, Anoosh Qayyum, Jehanzaib Islam, Gul Zaib, Haleema Saadia, and Ayesha Zahid. "Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery." Rawal Medical Journal 51.2 (2026), 552-556. Print.



APA (American Psychological Association) Style

Malik, A., Qayyum, . A., Islam, . J., Zaib, . G., Saadia, . H. & Zahid, . A. (2026) Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recovery. Rawal Medical Journal, 51 (2), 552-556.