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The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.

Shama Hashmani, Bushra Bano Patoli, Nimerta Kumari, Atif Ahmed Patoli, Shagufta Jabeen.

Abstract
Objective: To estimate the frequency of antibiotic resistance among the Staphylococci against a set of beta (β) lactam group of antibiotics.
Methodology: A total of 156 cultures of Staphylococci were isolated from clinical specimens and based on the coagulase production were categorized into two groups as; Coagulase Positive Staphylococci (CoPS) and Coagulase Negative Staphylococci (CoNS). The antibiotic resistance was determined using Kirby Baur disc diffusion method.
Results: Out of 156 isolates 57.6% (n=90) isolates were from male patients while 42.4% (n=66) were from female patients. About 62.1 % (n=97) of the isolates were CoPS while 37.9 % (n=59) were CoNS. Among CoPS the highest percentage of resistance (97.9%) was observed against penicillin G whereas among the CoNS the highest resistance was observed against Cefixime (93.2%). The comparative analysis for their potential to resist various members of beta-lactam antibiotics between CoPS and CoNS suggested non-significant differences for majority of the antibiotics used in this study. Comparatively higher resistance against amoxicillin was seen for CoPS (92.7%) than CoNS (79.6%). The odd ratio (OR) and confidence interval (CI 95%) for amoxicillin resistance between CoPS vs CoNS was calculated to be: 3.28 ( 1.21 8.89), while the p-values were determined to be 0.015 using chi square test of independence applying 2x2 contingency table. These values suggest a significant association of amoxicillin resistance with CoPS.
Conclusion: In general, beta-lactam antibiotic resistance in Staphylococcal isolates is observed greater in Hyderabad as compared to the previously described resistance in other regions of Pakistan.

Key words: Staphylococcus aureus, Coagulase-Negative Staphylococci (CoNs), beta-lactam antibiotics.


 
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How to Cite this Article
Pubmed Style

Hashmani S, Patoli BB, Kumari N, Patoli AA, Jabeen S. The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. RMJ. 2021; 46(1): 18-21.


Web Style

Hashmani S, Patoli BB, Kumari N, Patoli AA, Jabeen S. The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. http://www.rmj.org.pk/?mno=114214 [Access: March 20, 2021].


AMA (American Medical Association) Style

Hashmani S, Patoli BB, Kumari N, Patoli AA, Jabeen S. The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. RMJ. 2021; 46(1): 18-21.



Vancouver/ICMJE Style

Hashmani S, Patoli BB, Kumari N, Patoli AA, Jabeen S. The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. RMJ. (2021), [cited March 20, 2021]; 46(1): 18-21.



Harvard Style

Hashmani, S., Patoli, . B. B., Kumari, . N., Patoli, . A. A. & Jabeen, . S. (2021) The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. RMJ, 46 (1), 18-21.



Turabian Style

Hashmani, Shama, Bushra Bano Patoli, Nimerta Kumari, Atif Ahmed Patoli, and Shagufta Jabeen. 2021. The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. Rawal Medical Journal, 46 (1), 18-21.



Chicago Style

Hashmani, Shama, Bushra Bano Patoli, Nimerta Kumari, Atif Ahmed Patoli, and Shagufta Jabeen. "The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.." Rawal Medical Journal 46 (2021), 18-21.



MLA (The Modern Language Association) Style

Hashmani, Shama, Bushra Bano Patoli, Nimerta Kumari, Atif Ahmed Patoli, and Shagufta Jabeen. "The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.." Rawal Medical Journal 46.1 (2021), 18-21. Print.



APA (American Psychological Association) Style

Hashmani, S., Patoli, . B. B., Kumari, . N., Patoli, . A. A. & Jabeen, . S. (2021) The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad city of Pakistan.. Rawal Medical Journal, 46 (1), 18-21.








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