Abstract
Objective: To observe the histomorphological changes of isoniazid induced hepatotoxicity in male albino mice.
Methodology: This experimental study was carried out at University of Health Sciences, Lahore, Pakistan from January to December 2013. Forty male albino mice selected by simple random technique, were divided into two groups; A-Control, & B-experimental. Group A comprised of 15, while Group B comprised 25 mice. Both the groups were kept under identical conditions and diet. However, experimental group was treated with an additional oral hepatotoxic dose of isoniazid i.e. 100mg/kg bodyweight daily for 30 days. After 30 days, the animals were sacrificed and livers were dissected out. Gross comparison of the organ and stained sections were histologically compared for morphological differences between the groups. Fischer Exact test was used to analyze the qualitative data and a p<0.05 was considered significant.
Results: Group A animals showed the normal liver architecture. Whereas, those of Group B showed deranged hepatic histomorphology.
Conclusion: Hepatotoxic dose of Isoniazid caused histomorphological alterations in the liver of male albino mice.

Key words: Isoniazid, hepatotoxic, histomorphology.