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Original Research 


Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.

Nasir Siddique, Faisal Awais, Muhammad Shakil, Sadaf Sarwar, Nargis Haider Kakar, Muhammad Ikram Ullah.

Abstract
Objective: To compare the mean change in total symptom score (TSS) or neuropathic symptom score (NSS) in diabetic patients taking α-lipoic acid and in controls taking usual treatments.
Methodology: This randomized control trial study comprised of 110 patients who were divided into equal treatment group and control group. The mean change in TSS was determined in both groups. Data analysis was performed by using SPSS version 20.
Results: Mean age of patients with treatment group was 46.09±11.86 years and in control group 47.67±10.66 years. Male to female ratio was 1.03:1. The mean change in TSS in treatment group was 2.38±1.99 and in control group was 0.53±1.32 (p<0.001). The comparison of mean TSS score was significantly reduced for other variables (HbA1c, numbness, burning and paresthesia) in post-treatment group than the pretreatment group (p <0.001).
Conclusion: The mean change in TSS improved in diabetic patients taking α-lipoic acid and it showed significantly better effect and reduced the diabetic neuropathic pain in treated patients than controls.

Key words: Diabetes mellitus, complication, neuropathy.


 
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How to Cite this Article
Pubmed Style

Siddique N, Awais F, Shakil M, Sarwar S, Kakar NH, Ullah MI. Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. RMJ. 2021; 46(1): 33-36.

Web Style

Siddique N, Awais F, Shakil M, Sarwar S, Kakar NH, Ullah MI. Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. https://www.rmj.org.pk/?mno=82947 [Access: December 08, 2023].

AMA (American Medical Association) Style

Siddique N, Awais F, Shakil M, Sarwar S, Kakar NH, Ullah MI. Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. RMJ. 2021; 46(1): 33-36.


Vancouver/ICMJE Style

Siddique N, Awais F, Shakil M, Sarwar S, Kakar NH, Ullah MI. Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. RMJ. (2021), [cited December 08, 2023]; 46(1): 33-36.


Harvard Style

Siddique, N., Awais, . F., Shakil, . M., Sarwar, . S., Kakar, . N. H. & Ullah, . M. I. (2021) Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. RMJ, 46 (1), 33-36.


Turabian Style

Siddique, Nasir, Faisal Awais, Muhammad Shakil, Sadaf Sarwar, Nargis Haider Kakar, and Muhammad Ikram Ullah. 2021. Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. Rawal Medical Journal, 46 (1), 33-36.


Chicago Style

Siddique, Nasir, Faisal Awais, Muhammad Shakil, Sadaf Sarwar, Nargis Haider Kakar, and Muhammad Ikram Ullah. "Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.." Rawal Medical Journal 46 (2021), 33-36.


MLA (The Modern Language Association) Style

Siddique, Nasir, Faisal Awais, Muhammad Shakil, Sadaf Sarwar, Nargis Haider Kakar, and Muhammad Ikram Ullah. "Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.." Rawal Medical Journal 46.1 (2021), 33-36. Print.


APA (American Psychological Association) Style

Siddique, N., Awais, . F., Shakil, . M., Sarwar, . S., Kakar, . N. H. & Ullah, . M. I. (2021) Effect of anti-oxidant (α-lipoic acid) treatment on the improvement of diabetic neuropathic pain.. Rawal Medical Journal, 46 (1), 33-36.


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