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2024, Vol: 49, Issue: 3
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Review Article 


Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review

Maslichah Mafruchati, Jonathan Makuwira.


Abstract
Objective: To analyse Curcumin effect on proliferation, apoptosis, and hepatocyte differentiation of Balb/C Mice exposed to benzapyrene.
Methodology: A literature search was carried out systematically through the PubMed, NCBI, and Google Scholar databases using keywords, “Curcumin, Proliferation, Apoptosis and Hepatocyte Differentiation of Mice Balb/C, Benzapyrene”. Based on these keywords, the articles obtained were first selected by setting several inclusion criteria.
Results: A total of 550 articles were obtained for the keywords “Curcumin, Proliferation, Apoptosis and Hepatocyte Differentiation of Mice Balb/C, Benzapyrene and 28 met the inclusion criteria. Curcumin reduced the hepatocyte proliferation index in experimental animals exposed to BaP and increased the hepatocyte apoptosis index in experimental animals exposed to BaP. It reduced the N/C ratio of hepatocytes in experimental animals exposed to BaP.
Conclusion: Administration of curcumin in the diet during the initiation and post-initiation periods can inhibit the increase in PCNA expression, increase apoptosis, and improve hepatocyte differentiation patterns exposed to benzopyrene and curcumin.

Key words: Curcumin, proliferation, apoptosis, hepatocyte differentiation mice balb/C, benzapyrene.


 
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How to Cite this Article
Pubmed Style

Mafruchati M, Makuwira J. Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. RMJ. 2024; 49(3): 691-694. doi:10.5455/rmj.20230113082523

Web Style

Mafruchati M, Makuwira J. Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. https://www.rmj.org.pk/?mno=139114 [Access: September 13, 2024]. doi:10.5455/rmj.20230113082523

AMA (American Medical Association) Style

Mafruchati M, Makuwira J. Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. RMJ. 2024; 49(3): 691-694. doi:10.5455/rmj.20230113082523


Vancouver/ICMJE Style

Mafruchati M, Makuwira J. Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. RMJ. (2024), [cited September 13, 2024]; 49(3): 691-694. doi:10.5455/rmj.20230113082523


Harvard Style

Mafruchati, M. & Makuwira, . J. (2024) Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. RMJ, 49 (3), 691-694. doi:10.5455/rmj.20230113082523


Turabian Style

Mafruchati, Maslichah, and Jonathan Makuwira. 2024. Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. Rawal Medical Journal, 49 (3), 691-694. doi:10.5455/rmj.20230113082523


Chicago Style

Mafruchati, Maslichah, and Jonathan Makuwira. "Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review." Rawal Medical Journal 49 (2024), 691-694. doi:10.5455/rmj.20230113082523


MLA (The Modern Language Association) Style

Mafruchati, Maslichah, and Jonathan Makuwira. "Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review." Rawal Medical Journal 49.3 (2024), 691-694. Print. doi:10.5455/rmj.20230113082523


APA (American Psychological Association) Style

Mafruchati, M. & Makuwira, . J. (2024) Analysis of Curcumin on proliferation, apoptosis and differentiation of hepatocyte mice balb/C exposure to benzapyrene: A Systematic Review. Rawal Medical Journal, 49 (3), 691-694. doi:10.5455/rmj.20230113082523


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