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Original Research
Online Published: 06 May 2015
 
RMJ. 2015; 40(2): 197-202


Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial

Ghassan S.a. Salama, Fadi. F. Ayyash, Anas. J. Al-rabadi, Mohammad L. Alquran, Ayoub G. Shakkoury.


Abstract
Objective: This study aimed to compare nasal intermittent mandatory ventilation (N-IMV) versus nasal continuous positive airway pressure (N-CPAP) as an initial mode of respiratory support for premature infants with respiratory distress syndrome (RDS).
Method and patients : At Prince Hashem Ben Al- Hussein Military Hospital/ Jordan, a sixty premature infants born at gestational age 28-34 weeks with RDS, were divided into two equal groups: Group A: Connected through a nasal cannula to respirator using the IMV mode immediately after birth, and Group B:- Connected to bubble N-CPAP driver. Arterial blood gases (ABGs) were observed, and a daily chest x- rays were taken. All included infants evaluated clinically on a daily base, throughout the period of the study. Effect, failure, and complications of each method evaluated and compared.
Results: A total of 60 premature infants (32 males and 28 females) with gestational age 28- 34 weeks and birth weight 0.880- 2.0 kg were included. N-IMV associated with almost ideal physiological arterial gases (mean PaCO2=37.5mmHg, mean PaO2=82.5 mmHg, mean O2 sat=95%, mean pH=7.32 and mean HCO3=19.2mmol/l), where N-CPAP associated with CO2 retention and acidosis (mean PaCO2=53 mmHg and mean pH=7.23). Infants in the N-IMV group had less occurrence of pneumothorax, secondary chest infection , late sepsis, and bronchopulmonary dysplasia (BPD) meanwhile, gastrointestinal perforation and abdominal distention were common in N-CPAP group.
Conclusion: N-IMV associated to a more physiological arterial gases, no pneumothorax, and absence of abdominal complications and nasal deformity, all of which making it superior to N-CPAP.

Key words: Premature, surfactant, ventilation.


 
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How to Cite this Article
Pubmed Style

Salama GS, Ayyash FF, Al-rabadi AJ, Alquran ML, Shakkoury AG. Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. RMJ. 2015; 40(2): 197-202.

Web Style

Salama GS, Ayyash FF, Al-rabadi AJ, Alquran ML, Shakkoury AG. Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. https://www.rmj.org.pk/?mno=173370 [Access: June 22, 2026].

AMA (American Medical Association) Style

Salama GS, Ayyash FF, Al-rabadi AJ, Alquran ML, Shakkoury AG. Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. RMJ. 2015; 40(2): 197-202.


Vancouver/ICMJE Style

Salama GS, Ayyash FF, Al-rabadi AJ, Alquran ML, Shakkoury AG. Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. RMJ. (2015), [cited June 22, 2026]; 40(2): 197-202.


Harvard Style

Salama, G. S., Ayyash, . F. F., Al-rabadi, . A. J., Alquran, . M. L. & Shakkoury, . A. G. (2015) Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. RMJ, 40 (2), 197-202.


Turabian Style

Salama, Ghassan S.a., Fadi. F. Ayyash, Anas. J. Al-rabadi, Mohammad L. Alquran, and Ayoub G. Shakkoury. 2015. Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. Rawal Medical Journal, 40 (2), 197-202.


Chicago Style

Salama, Ghassan S.a., Fadi. F. Ayyash, Anas. J. Al-rabadi, Mohammad L. Alquran, and Ayoub G. Shakkoury. "Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial." Rawal Medical Journal 40 (2015), 197-202.


MLA (The Modern Language Association) Style

Salama, Ghassan S.a., Fadi. F. Ayyash, Anas. J. Al-rabadi, Mohammad L. Alquran, and Ayoub G. Shakkoury. "Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial." Rawal Medical Journal 40.2 (2015), 197-202. Print.


APA (American Psychological Association) Style

Salama, G. S., Ayyash, . F. F., Al-rabadi, . A. J., Alquran, . M. L. & Shakkoury, . A. G. (2015) Nasal -IMV versus Nasal-CPAP as an initial mode of respiratory support for premature infants with RD: A prospective randomized clinical trial. Rawal Medical Journal, 40 (2), 197-202.


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