Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population

Muhammed Hassan Siddiqui; Ayesha Khan; Arif Ali; Shahzad Ali; Naresh Kumar Valecha; Farooque Ahmed

2025, Vol: 50, Issue: 4

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RMJ. 2025; 50(4): 940-943

Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population

Muhammed Hassan Siddiqui, Ayesha Khan, Arif Ali, Shahzad Ali, Naresh Kumar Valecha, Farooque Ahmed.

Abstract
Objective: To determine the antibiotic susceptibility in the commonly identified orgaersms associated with upper tract calculi in a tertiary care hospital.
Methodology: This prospective cross-sectional study was conducted in the Department of Urology and included 368 patients with urinary tract infections and upper tract calculi. Microbiological testing was performed to identify the uropathogens involved and their antibiotic susceptibility patterns were determined. Descriptive statistics were used.
Results: Escherichia coli were the most frequently identified (41.3%) organism, followed by Pseudomonas (17.1%), coagulase-positive staphylococci (13.6%), and Klebsiella pneumonia (11.7%). The microorganisms showed high susceptibility to Tazobactam-Piperacillin, Carbapenems, Amikacin, Fosfomycin and Nitrofurantoin. Conversely, high resistance rates were observed against commonly prescribed antibiotics such as Fluoroquinolones and Cephalosporins.
Conclusion: In patients with urolithiasis, E. coli was the organism most frequently responsible for urinary tract infections. Most common effective antibiotics were tazobactam-pipercillin, carbapenem, amikacin, fosfomycin and nitrofurantoin. Conversely flouroquinolones and cephalosporines were found to be resistant.

Key words: Uropathogens, antimicrobial susceptibility, urinary tract infection, upper urinary tract stone disease.

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How to Cite this Article

Pubmed Style

Siddiqui MH, Khan A, Ali A, Ali S, Valecha NK, Ahmed F. Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. RMJ. 2025; 50(4): 940-943.

Web Style

Siddiqui MH, Khan A, Ali A, Ali S, Valecha NK, Ahmed F. Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. https://www.rmj.org.pk/?mno=181121 [Access: October 30, 2025].

AMA (American Medical Association) Style

Siddiqui MH, Khan A, Ali A, Ali S, Valecha NK, Ahmed F. Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. RMJ. 2025; 50(4): 940-943.

Vancouver/ICMJE Style

Siddiqui MH, Khan A, Ali A, Ali S, Valecha NK, Ahmed F. Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. RMJ. (2025), [cited October 30, 2025]; 50(4): 940-943.

Harvard Style

Siddiqui, M. H., Khan, . A., Ali, . A., Ali, . S., Valecha, . N. K. & Ahmed, . F. (2025) Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. RMJ, 50 (4), 940-943.

Turabian Style

Siddiqui, Muhammed Hassan, Ayesha Khan, Arif Ali, Shahzad Ali, Naresh Kumar Valecha, and Farooque Ahmed. 2025. Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population. Rawal Medical Journal, 50 (4), 940-943.

Chicago Style

Siddiqui, Muhammed Hassan, Ayesha Khan, Arif Ali, Shahzad Ali, Naresh Kumar Valecha, and Farooque Ahmed. "Antibiotic susceptibility in commonly isolated uropathogens with urinary calculi in Pakistani population." Rawal Medical Journal 50 (2025), 940-943.

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