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RMJ. 2024; 49(3): 493-496


Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study

Saad Najam, Samia Perwaiz, Rizwana Warraich, Ajeet Kumar, Nosheen Iqbal, Syeda Urooj.


Abstract
Objective: To determine the prevalence and risk factors of anti-tuberculosis drug induced liver injury (AT-DILI) while assessing gender differences and documenting incidence trends.
Methodology: We utilized a questionnaire survey, collection of sputum samples for acid-fast bacilli testing and liver function tests (LFTs).
Results: Out 100 patients, 35 were males and 65 females. A total of 45 patients were tested positive for acid-fast bacilli (AFB) on smear. Most patients exhibited regular LFT results, signifying unremarkable hepatic function during TB therapy. However, among relapse and post-TB cases, abnormal LFT findings were often accompanied by jaundice.
Conclusion: Among relapse and post-TB cases, abnormal LFT findings were often accompanied by jaundice. Further research is needed to elucidate mechanisms behind this increased vulnerability to prevent AT-DILI in populations.

Key words: Anti-tuberculosis drug therapy, drug-induced liver injury, DILI, Abnormal Liver function, Jaundice.


 
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How to Cite this Article
Pubmed Style

Najam S, Perwaiz S, Warraich R, Kumar A, Iqbal N, Urooj S. Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. RMJ. 2024; 49(3): 493-496.

Web Style

Najam S, Perwaiz S, Warraich R, Kumar A, Iqbal N, Urooj S. Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. https://www.rmj.org.pk/?mno=188885 [Access: September 12, 2024].

AMA (American Medical Association) Style

Najam S, Perwaiz S, Warraich R, Kumar A, Iqbal N, Urooj S. Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. RMJ. 2024; 49(3): 493-496.


Vancouver/ICMJE Style

Najam S, Perwaiz S, Warraich R, Kumar A, Iqbal N, Urooj S. Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. RMJ. (2024), [cited September 12, 2024]; 49(3): 493-496.


Harvard Style

Najam, S., Perwaiz, . S., Warraich, . R., Kumar, . A., Iqbal, . N. & Urooj, . S. (2024) Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. RMJ, 49 (3), 493-496.


Turabian Style

Najam, Saad, Samia Perwaiz, Rizwana Warraich, Ajeet Kumar, Nosheen Iqbal, and Syeda Urooj. 2024. Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. Rawal Medical Journal, 49 (3), 493-496.


Chicago Style

Najam, Saad, Samia Perwaiz, Rizwana Warraich, Ajeet Kumar, Nosheen Iqbal, and Syeda Urooj. "Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study." Rawal Medical Journal 49 (2024), 493-496.


MLA (The Modern Language Association) Style

Najam, Saad, Samia Perwaiz, Rizwana Warraich, Ajeet Kumar, Nosheen Iqbal, and Syeda Urooj. "Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study." Rawal Medical Journal 49.3 (2024), 493-496. Print.


APA (American Psychological Association) Style

Najam, S., Perwaiz, . S., Warraich, . R., Kumar, . A., Iqbal, . N. & Urooj, . S. (2024) Incidence of anti-tuberculosis drug induced liver injuries in patients receiving therapy-at a tertiary care hospital in Karachi: A cross-sectional study. Rawal Medical Journal, 49 (3), 493-496.


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