ISSN 0303-5212
 

Original Research 
RMJ. 2024; 49(4): 742-745


Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches

Musaddiq Hussain Bangash, Fakhra Noureen, Naseer Uddin, Ama Tul Naval, Ehsan Khan, Seemi Tanvir.


Abstract
Objective: To explore nephropathological association in diabetic UTIs based on neutrophil percentage to albumin ratio (NPAR) as an integrated biomarker.
Methodology: This sectional cross-sectional retrospective study included 102 patients (diabetic UTIs patients n=78, healthy controls n=24) with 60 females and 42 males with UTIs seen at Shaikh Zayed Hospital, Lahore. Clinical confounders (e.g., HbA1c, fasting glucose, dysuria, urgent urine frequency, chills, hematuria, and frequent flank pain (pyelonephritis) were assessed along with an integrated biomarker NPAR (ml/g) analysis. Statistical analyses were performed via SPSS 26.0 using T-test and Pearson Correlation.
Results: The mean age of participants (n=102) was 50.5±5.29 years, with 60 (59%) females and 42 (41%) males. Diabetic UTIs confounders were recorded as HbA1c (11.10±1.61%), Fasting Glucose levels (8.36± 0.92 mmol/L), dysuria (82%), frequency (72%), chills (49%), hematuria (46%), suprapubic discomfort (52%) and frequent flank (pyelonephritis) pain (32%). Mean NPAR had (2.07±0.04) a significant correlation (Pearson coefficient r=0.51) between NPAR and severity of UTIs (p<0.05).
Conclusion: This study suggests that NPAR may serve as a promising pathological assessment biomarker for diagnosing UTIs in diabetic individuals. Further clinical research is warranted to validate the diagnostic accuracy.

Key words: Nephropathology, urinary tract infections, diabetes, neutrophil percentage to albumin ratio (NPAR), infection diagnostics.


 
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How to Cite this Article
Pubmed Style

Bangash MH, Noureen F, Uddin N, Naval AT, Khan E, Tanvir S. Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. RMJ. 2024; 49(4): 742-745.


Web Style

Bangash MH, Noureen F, Uddin N, Naval AT, Khan E, Tanvir S. Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. https://www.rmj.org.pk/?mno=216283 [Access: January 22, 2025].


AMA (American Medical Association) Style

Bangash MH, Noureen F, Uddin N, Naval AT, Khan E, Tanvir S. Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. RMJ. 2024; 49(4): 742-745.



Vancouver/ICMJE Style

Bangash MH, Noureen F, Uddin N, Naval AT, Khan E, Tanvir S. Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. RMJ. (2024), [cited January 22, 2025]; 49(4): 742-745.



Harvard Style

Bangash, M. H., Noureen, . F., Uddin, . N., Naval, . A. T., Khan, . E. & Tanvir, . S. (2024) Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. RMJ, 49 (4), 742-745.



Turabian Style

Bangash, Musaddiq Hussain, Fakhra Noureen, Naseer Uddin, Ama Tul Naval, Ehsan Khan, and Seemi Tanvir. 2024. Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. Rawal Medical Journal, 49 (4), 742-745.



Chicago Style

Bangash, Musaddiq Hussain, Fakhra Noureen, Naseer Uddin, Ama Tul Naval, Ehsan Khan, and Seemi Tanvir. "Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches." Rawal Medical Journal 49 (2024), 742-745.



MLA (The Modern Language Association) Style

Bangash, Musaddiq Hussain, Fakhra Noureen, Naseer Uddin, Ama Tul Naval, Ehsan Khan, and Seemi Tanvir. "Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches." Rawal Medical Journal 49.4 (2024), 742-745. Print.



APA (American Psychological Association) Style

Bangash, M. H., Noureen, . F., Uddin, . N., Naval, . A. T., Khan, . E. & Tanvir, . S. (2024) Nephropathological associations: Diagnostic insights into diabetic UTIs via integrated biomarker approaches. Rawal Medical Journal, 49 (4), 742-745.