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Original Research 
RMJ. 2016; 41(4): 487-491


Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin

Ayesha Janjua, Akbar Waheed, Salman Bakhtiar.


Abstract
Objective: To evaluate potential role of metformin in protecting kidneys from nephrotoxicant insult.
Methods: Twenty four rabbits were randomly divided into four groups (n=6). G-1 received 1 ml isotonic saline intraperitoneally(IP) daily for 13 days. G-2 received daily gentamicin(40 mg/kg/day)IP for 13 days. G-3 received metformin salt (100 mg/kg/day) dissolved in drinking water via feeding tube for 13 days. G-4 received metformin salt (100 mg/kg/day) via feeding tube plus gentamicin(40 mg/kg/day)IP for 13 days. Blood was collected on days 0 and 14 for serum urea & creatinine estimation. All animals were sacrificed and kidneys were removed for renal histological examination.
Results: Metformin showed nephroprotective effect.
Conclusion: Metformin offers complete nephrotection when administered along with nephrotoxic dose of gentamicin. This could offer an efficacious and cheaper treatment alternative in those diabetics who also suffer from gram negative infections.

Key words: Nephrotoxicity, Nephroprotection, Renoprotection, Gentamicin, Metformin,


 
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Pubmed Style

Janjua A, Waheed A, Bakhtiar S. Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. RMJ. 2016; 41(4): 487-491.

Web Style

Janjua A, Waheed A, Bakhtiar S. Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. https://www.rmj.org.pk/?mno=228833 [Access: June 27, 2026].

AMA (American Medical Association) Style

Janjua A, Waheed A, Bakhtiar S. Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. RMJ. 2016; 41(4): 487-491.


Vancouver/ICMJE Style

Janjua A, Waheed A, Bakhtiar S. Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. RMJ. (2016), [cited June 27, 2026]; 41(4): 487-491.


Harvard Style

Janjua, A., Waheed, . A. & Bakhtiar, . S. (2016) Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. RMJ, 41 (4), 487-491.


Turabian Style

Janjua, Ayesha, Akbar Waheed, and Salman Bakhtiar. 2016. Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. Rawal Medical Journal, 41 (4), 487-491.


Chicago Style

Janjua, Ayesha, Akbar Waheed, and Salman Bakhtiar. "Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin." Rawal Medical Journal 41 (2016), 487-491.


MLA (The Modern Language Association) Style

Janjua, Ayesha, Akbar Waheed, and Salman Bakhtiar. "Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin." Rawal Medical Journal 41.4 (2016), 487-491. Print.


APA (American Psychological Association) Style

Janjua, A., Waheed, . A. & Bakhtiar, . S. (2016) Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin. Rawal Medical Journal, 41 (4), 487-491.


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