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Original Research 
RMJ. 2025; 50(2): 496-500


Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia

Farooq Sultan, Tehreem Zulfiqar, Bisma Fatima Aslam, Sadia Maqsood, Saadia Shahzad Alam, Mudassara Saqib.


Abstract
Objective: To assess the histological effects of simvastatin and Ajwa date seed extract on non-alcoholic fatty liver disease (NAFLD).
Methodology: It is an in-vitro experimental animal study, 5 groups of eight rats each were created. Group 1 was a healthy control group. In Group, 2 animals were fed with butter for 36 days and left untreated. Group 3 and 4 were treated with simvastatin 10mg/kg/day and Aqueous extract of Seeds of Ajwa date (ADSE) 8ml/kg/day, respectively. Group 5 received simvastatin and ADSE together in half recommended doses that is 5mg/kg/day and 4ml/kg/day, respectively. Hyperlipidaemia was induced in 15 days and treatment with simvastatin and ADSE continued for 21 days making it 36 days study. Then animals were sacrificed, liver samples were eosin haematoxylin stained. The histopathological characteristics were statistically analysed using Fisher's exact test.
Results: Simvastatin & ADSE when used individually and together showed considerable hepatoprotective effects against NAFLD. However, the group that received half dose combination showed fewer promising effects.
Conclusion: Ajwa date seed may have therapeutic potential in NAFLD.

Key words: Hyperlipidemia, ajwa date seed, simvastatin.


 
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How to Cite this Article
Pubmed Style

Sultan F, Zulfiqar T, Aslam BF, Maqsood S, Alam SS, Saqib M. Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. RMJ. 2025; 50(2): 496-500.

Web Style

Sultan F, Zulfiqar T, Aslam BF, Maqsood S, Alam SS, Saqib M. Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. https://www.rmj.org.pk/?mno=234928 [Access: May 12, 2025].

AMA (American Medical Association) Style

Sultan F, Zulfiqar T, Aslam BF, Maqsood S, Alam SS, Saqib M. Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. RMJ. 2025; 50(2): 496-500.


Vancouver/ICMJE Style

Sultan F, Zulfiqar T, Aslam BF, Maqsood S, Alam SS, Saqib M. Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. RMJ. (2025), [cited May 12, 2025]; 50(2): 496-500.


Harvard Style

Sultan, F., Zulfiqar, . T., Aslam, . B. F., Maqsood, . S., Alam, . S. S. & Saqib, . M. (2025) Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. RMJ, 50 (2), 496-500.


Turabian Style

Sultan, Farooq, Tehreem Zulfiqar, Bisma Fatima Aslam, Sadia Maqsood, Saadia Shahzad Alam, and Mudassara Saqib. 2025. Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. Rawal Medical Journal, 50 (2), 496-500.


Chicago Style

Sultan, Farooq, Tehreem Zulfiqar, Bisma Fatima Aslam, Sadia Maqsood, Saadia Shahzad Alam, and Mudassara Saqib. "Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia." Rawal Medical Journal 50 (2025), 496-500.


MLA (The Modern Language Association) Style

Sultan, Farooq, Tehreem Zulfiqar, Bisma Fatima Aslam, Sadia Maqsood, Saadia Shahzad Alam, and Mudassara Saqib. "Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia." Rawal Medical Journal 50.2 (2025), 496-500. Print.


APA (American Psychological Association) Style

Sultan, F., Zulfiqar, . T., Aslam, . B. F., Maqsood, . S., Alam, . S. S. & Saqib, . M. (2025) Effects of simvastatin and aqueous extract of seeds of ajwa dates on Non-Alcoholic Fatty Liver Disease in a rat model of dyslipidemia. Rawal Medical Journal, 50 (2), 496-500.


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