Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris

Mushayada Irshad; Mehreen Mirza; Muhammad Waseem Shahid; Afifa Siddique; Ammara Amjad; Salma Salim

2026, Vol: 51, Issue: 1

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Original Research

RMJ. 2026; 51(1): 95-98

doi: 10.5455/rmj.20250430040714

Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris

Mushayada Irshad, Mehreen Mirza, Muhammad Waseem Shahid, Afifa Siddique, Ammara Amjad, Salma Salim.

Abstract
Objective: To compare the efficacy of oral azithromycin with oral probiotics, and with the combination of both in improving the patients’ quality of life (QOL).
Methodology: A total of 75 patients who had mild and moderate acne were enrolled and categorized into three groups. The first Group A, was given tab. azithromycin (250mg oral every other day), Group B was given probiotics i.e., Hi-Flora sachet (1 sachet oral every day) & Group C was given both tab. azithromycin and probiotics. Patients’ satisfaction was assessed by a questionnaire, “Dermatology Life Quality Index (DLQI).” Efficacy of regimens was measured by calculating the difference in mean DLQI score at the start and the end of treatment i.e., after 3 months.
Results: All three groups showed significant improvement in QOL. Group A showed a reduction in mean DLQI score by 68.9%, group B by 67.2% and group C by 72.2%.
Conclusion: The combination of azithromycin and probiotics was significantly more effective than azithromycin alone in improving QOL in patients with acne vulgaris.

Key words: Acne vulgaris, treatment efficacy, azithromycin, probiotics.

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How to Cite this Article

Pubmed Style

Irshad M, Mirza M, Shahid MW, Siddique A, Amjad A, Salim S. Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. RMJ. 2026; 51(1): 95-98. doi:10.5455/rmj.20250430040714

Web Style

Irshad M, Mirza M, Shahid MW, Siddique A, Amjad A, Salim S. Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. https://www.rmj.org.pk/?mno=255262 [Access: February 25, 2026]. doi:10.5455/rmj.20250430040714

AMA (American Medical Association) Style

Irshad M, Mirza M, Shahid MW, Siddique A, Amjad A, Salim S. Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. RMJ. 2026; 51(1): 95-98. doi:10.5455/rmj.20250430040714

Vancouver/ICMJE Style

Irshad M, Mirza M, Shahid MW, Siddique A, Amjad A, Salim S. Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. RMJ. (2026), [cited February 25, 2026]; 51(1): 95-98. doi:10.5455/rmj.20250430040714

Harvard Style

Irshad, M., Mirza, . M., Shahid, . M. W., Siddique, . A., Amjad, . A. & Salim, . S. (2026) Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. RMJ, 51 (1), 95-98. doi:10.5455/rmj.20250430040714

Turabian Style

Irshad, Mushayada, Mehreen Mirza, Muhammad Waseem Shahid, Afifa Siddique, Ammara Amjad, and Salma Salim. 2026. Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris. Rawal Medical Journal, 51 (1), 95-98. doi:10.5455/rmj.20250430040714

Chicago Style

Irshad, Mushayada, Mehreen Mirza, Muhammad Waseem Shahid, Afifa Siddique, Ammara Amjad, and Salma Salim. "Treatment efficacy of azithromycin and probiotics in improving quality of life in patients with acne vulgaris." Rawal Medical Journal 51 (2026), 95-98. doi:10.5455/rmj.20250430040714

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APA (American Psychological Association) Style

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