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2026, Vol: 51, Issue: 1
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Review Article 


Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies

Herwindo Ahmad, Naomi Niari Dalimunthe, Refli Hasan, Maggie Liberty.


Abstract
Objective: To assess the comprehensive overview of alcohol mediated renal denervation (RDN) for resistant hypertension, including its mechanism of action and recent evidence on its efficacy and safety.
Methodology: PubMed/MEDLINE, ScienceDirect, and Cochrane Library were searched comprehensively for studies evaluating alcohol mediated RDN for resistant hypertension. The included studies were assessed for the quality of study methods and reported data.
Results: Data were collected and synthesized narratively, summarizing various research findings of alcohol mediated RDN.
Conclusion: Alcohol-mediated RDN significantly lowers 24-h ambulatory and office systolic and diastolic blood pressure at 3- and 6-month follow-up. Moreover, its effects persisted up to 24 months post-procedure. Additionally, alcohol mediated RDN using the Peregrine catheter is safe and well-tolerated with minimal adverse events.

Key words: Renal denervation, renal sympathetic denervation, resistant hypertension, alcohol-mediated.


 
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How to Cite this Article
Pubmed Style

Ahmad H, Dalimunthe NN, Hasan R, Liberty M. Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. RMJ. 2026; 51(1): 260-264. doi:10.5455/rmj.20250508032312

Web Style

Ahmad H, Dalimunthe NN, Hasan R, Liberty M. Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. https://www.rmj.org.pk/?mno=256899 [Access: February 21, 2026]. doi:10.5455/rmj.20250508032312

AMA (American Medical Association) Style

Ahmad H, Dalimunthe NN, Hasan R, Liberty M. Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. RMJ. 2026; 51(1): 260-264. doi:10.5455/rmj.20250508032312


Vancouver/ICMJE Style

Ahmad H, Dalimunthe NN, Hasan R, Liberty M. Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. RMJ. (2026), [cited February 21, 2026]; 51(1): 260-264. doi:10.5455/rmj.20250508032312


Harvard Style

Ahmad, H., Dalimunthe, . N. N., Hasan, . R. & Liberty, . M. (2026) Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. RMJ, 51 (1), 260-264. doi:10.5455/rmj.20250508032312


Turabian Style

Ahmad, Herwindo, Naomi Niari Dalimunthe, Refli Hasan, and Maggie Liberty. 2026. Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. Rawal Medical Journal, 51 (1), 260-264. doi:10.5455/rmj.20250508032312


Chicago Style

Ahmad, Herwindo, Naomi Niari Dalimunthe, Refli Hasan, and Maggie Liberty. "Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies." Rawal Medical Journal 51 (2026), 260-264. doi:10.5455/rmj.20250508032312


MLA (The Modern Language Association) Style

Ahmad, Herwindo, Naomi Niari Dalimunthe, Refli Hasan, and Maggie Liberty. "Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies." Rawal Medical Journal 51.1 (2026), 260-264. Print. doi:10.5455/rmj.20250508032312


APA (American Psychological Association) Style

Ahmad, H., Dalimunthe, . N. N., Hasan, . R. & Liberty, . M. (2026) Exploring catheter-based alcohol-mediated renal denervation for the treatment of resistant hypertension: Comprehensive review of current interventional studies. Rawal Medical Journal, 51 (1), 260-264. doi:10.5455/rmj.20250508032312


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