Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan

Sajjad Hussain Qureshi; Naeem Ul Karim Bhatti; Shahnawz Lighari; Maimoona Khushk; Abdul Rahim Memon; Humaira Yousif

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RMJ. 2025; 50(4): 902-906

Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan

Sajjad Hussain Qureshi, Naeem Ul Karim Bhatti, Shahnawz Lighari, Maimoona Khushk, Abdul Rahim Memon, Humaira Yousif.

Abstract
Objective: To investigate immunotherapy as an adjuvant treatment following surgery for individuals with advanced colorectal cancer (CRC).
Methodology: This clinical trial included 110 colorectal patients of both sexes aged between 18–75 years divided randomly into two groups. In the intervention group, participants were administered a programmed cell death protein 1 (PD-1) inhibitor; in the control group, the 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) regimen was administered. These were followed by recurrence-free survival (RFS) and overall survival (OS) as well as immune response variables, particularly the count of Cluster of Differentiation 8 Positive (CD8+) T cells.
Results: The study involved 110 patients with no significant differences in their demographic data or disease characteristics between the two groups. The immunotherapy group had improved one-year RFS and OS as compared to the chemotherapy group; however, such differences were not significant. Immunotherapy produced a higher quality of life (QoL) and elevated levels of CD8+T cells at 6 and 12 months (p=0.0001). Univariate and multivariate analyses confirmed immunotherapy’s significant protective effect on recurrence (p=0.03).
Conclusion: The immunotherapy did appear to have better RFS and OS. This study found higher levels of CD8+ T cells and a better QoL to support that immunotherapy may be effective in complementing the current treatment for advanced CRC.

Key words: Immunotherapy, colorectal cancer, chemotherapy, recurrence-free survival, quality of life.

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Pubmed Style

Qureshi SH, Bhatti NUK, Lighari S, Khushk M, Memon AR, Yousif H. Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan. RMJ. 2025; 50(4): 902-906.

Web Style

Qureshi SH, Bhatti NUK, Lighari S, Khushk M, Memon AR, Yousif H. Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan. https://www.rmj.org.pk/?mno=261564 [Access: October 30, 2025].

AMA (American Medical Association) Style

Qureshi SH, Bhatti NUK, Lighari S, Khushk M, Memon AR, Yousif H. Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan. RMJ. 2025; 50(4): 902-906.

Vancouver/ICMJE Style

Harvard Style

Qureshi, S. H., Bhatti, . N. U. K., Lighari, . S., Khushk, . M., Memon, . A. R. & Yousif, . H. (2025) Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan. RMJ, 50 (4), 902-906.

Turabian Style

Qureshi, Sajjad Hussain, Naeem Ul Karim Bhatti, Shahnawz Lighari, Maimoona Khushk, Abdul Rahim Memon, and Humaira Yousif. 2025. Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan. Rawal Medical Journal, 50 (4), 902-906.

Chicago Style

Qureshi, Sajjad Hussain, Naeem Ul Karim Bhatti, Shahnawz Lighari, Maimoona Khushk, Abdul Rahim Memon, and Humaira Yousif. "Exploring the role of Immunotherapy as an adjuvant to surgical resection in advanced colorectal patients: A clinical trial from Nawabshah, Pakistan." Rawal Medical Journal 50 (2025), 902-906.

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