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RMJ. 2025; 50(4): 1046-1050


Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population

Sana Barkat Ali Bhayani, Saifullah Shaikh, Sagheer Uddin, Saira Hassan Askarey, Maria Ali, Zahra Tapal Lotya.


Abstract
Objective: To compare the association between thromboembolic events and cardiovascular risk with ABO Blood Groups.
Methodology: This cross-sectional study included a total of 349 participants. All were aged 35-55 years were selected for the cardio risk program that generated a score, known as the cardiac risk score, calculated as Total cholesterol/HDL. The ratio greater than 4.5 was considered a high risk for CHD. Non-O Blood group (A and B) was collected to determine the variables like serum cholesterol, LDL, triglyceride, and HDL levels, which are the prognostic tools for the risk of cardiovascular disease. Statistical analysis was performed using SPSS version 23. One-way ANOVA and Chi-square test were applied, and p<0.05 was considered statistically significant.
Results: Cholesterol was observed to be significant with p<0.0001 and a mean value of 189.08±9.11 in blood group A-. Triglycerides were significant with p<0.0001, and the highest mean value of 206.77±12.15 was observed in A- blood group. HDL had the highest mean value of 90.63±58.76 in AB+ blood group with p<0.0001. LDL had the highest mean value of 132.71±33.60 in AB+ blood group with p<0.0001.
Conclusion: The results of this study underline both; key role of ABO blood group for the risk of developing arterial thrombotic events and the need for including such an unmodifiable variable in the scores assessing the thrombotic risk.

Key words: ABO blood group, cardiac risk score, CVDs and thrombo-embolic events.


 
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How to Cite this Article
Pubmed Style

Bhayani SBA, Shaikh S, Uddin S, Askarey SH, Ali M, Lotya ZT. Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. RMJ. 2025; 50(4): 1046-1050.

Web Style

Bhayani SBA, Shaikh S, Uddin S, Askarey SH, Ali M, Lotya ZT. Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. https://www.rmj.org.pk/?mno=266290 [Access: October 30, 2025].

AMA (American Medical Association) Style

Bhayani SBA, Shaikh S, Uddin S, Askarey SH, Ali M, Lotya ZT. Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. RMJ. 2025; 50(4): 1046-1050.


Vancouver/ICMJE Style

Bhayani SBA, Shaikh S, Uddin S, Askarey SH, Ali M, Lotya ZT. Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. RMJ. (2025), [cited October 30, 2025]; 50(4): 1046-1050.


Harvard Style

Bhayani, S. B. A., Shaikh, . S., Uddin, . S., Askarey, . S. H., Ali, . M. & Lotya, . Z. T. (2025) Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. RMJ, 50 (4), 1046-1050.


Turabian Style

Bhayani, Sana Barkat Ali, Saifullah Shaikh, Sagheer Uddin, Saira Hassan Askarey, Maria Ali, and Zahra Tapal Lotya. 2025. Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. Rawal Medical Journal, 50 (4), 1046-1050.


Chicago Style

Bhayani, Sana Barkat Ali, Saifullah Shaikh, Sagheer Uddin, Saira Hassan Askarey, Maria Ali, and Zahra Tapal Lotya. "Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population." Rawal Medical Journal 50 (2025), 1046-1050.


MLA (The Modern Language Association) Style

Bhayani, Sana Barkat Ali, Saifullah Shaikh, Sagheer Uddin, Saira Hassan Askarey, Maria Ali, and Zahra Tapal Lotya. "Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population." Rawal Medical Journal 50.4 (2025), 1046-1050. Print.


APA (American Psychological Association) Style

Bhayani, S. B. A., Shaikh, . S., Uddin, . S., Askarey, . S. H., Ali, . M. & Lotya, . Z. T. (2025) Exploring the association between cardiovascular disease risk and ABO Blood Group phenotypes in Karachi-based healthy population. Rawal Medical Journal, 50 (4), 1046-1050.


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