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Original Research 
RMJ. 2018; 43(2): 349-353


Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam.


Abstract
Objective: To compare serum levels of 8-isoprostane and arterial stiffness index (ASI) in normotensive, prehypertensive and hypertensive subjects and to ascertain its correlation with ASI and blood pressure.
Methodology: We studied a total of ninety male subjects ranging from 35-55 years of age. They were classified into normotensive, prehypertensive and hypertensive groups in light of JNC-8 Guidelines. Each group comprised of thirty subjects. Blood pressure was measured with mercury sphygmomanometer and digital volume pulse was recorded by photoplethysmography and ASI was calculated. Serum 8-isoprostane levels were measured by ELISA.
Results: Serum 8-isoprostane levels and ASI were significantly (0.0001) different amongst the three groups. The Post Hoc Tukey’s Test revealed p-value of 0.006 between normotensive and prehypertensive groups and 0.0001 between prehypertensive and hypertensive as well as normotensive and hypertensive groups for ASI. Plasma 8-isoprostane levels were non-significant (0.113) between normotensive and prehypertensive groups while significant (0.0001) between prehypertensive and hypertensive as well as normotensive and hypertensive groups. In normotensive subjects, the relationship between serum 8-isoprostane levels was moderately (r=0.4) correlated with ASI while, it was relatively strongly related with ASI in prehypertensive (r = 0.5) and hypertensive (r = 0.5) subjects.
Conclusion: The oxidative stress is involved in the development and worsening of arterial stiffness in prehypertensive and hypertensive patients.

Key words: Prehypertension, hypertension, arterial stiffness index, 8-isoprostane levels, oxidative stress.


 
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How to Cite this Article
Pubmed Style

Mehmood MS, Hussain MM, Imam KA. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. 2018; 43(2): 349-353.

Web Style

Mehmood MS, Hussain MM, Imam KA. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. https://www.rmj.org.pk/?mno=276688 [Access: May 13, 2025].

AMA (American Medical Association) Style

Mehmood MS, Hussain MM, Imam KA. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. 2018; 43(2): 349-353.


Vancouver/ICMJE Style

Mehmood MS, Hussain MM, Imam KA. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. (2018), [cited May 13, 2025]; 43(2): 349-353.


Harvard Style

Mehmood, M. S., Hussain, . M. M. & Imam, . K. A. (2018) Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ, 43 (2), 349-353.


Turabian Style

Mehmood, Muhammad Sajid, Muhammad Mazhar Hussain, and Kamil Asghar Imam. 2018. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. Rawal Medical Journal, 43 (2), 349-353.


Chicago Style

Mehmood, Muhammad Sajid, Muhammad Mazhar Hussain, and Kamil Asghar Imam. "Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects." Rawal Medical Journal 43 (2018), 349-353.


MLA (The Modern Language Association) Style

Mehmood, Muhammad Sajid, Muhammad Mazhar Hussain, and Kamil Asghar Imam. "Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects." Rawal Medical Journal 43.2 (2018), 349-353. Print.


APA (American Psychological Association) Style

Mehmood, M. S., Hussain, . M. M. & Imam, . K. A. (2018) Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. Rawal Medical Journal, 43 (2), 349-353.


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