ISSN 0303-5212
 
2023, Vol: 48, Issue: 2
48 / 2Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author certificate
Bank Reciept

Original Research 
RMJ. 2018; 43(2): 349-353


Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam.

Abstract
Objective: To compare serum levels of 8-isoprostane and arterial stiffness index (ASI) in normotensive, prehypertensive and hypertensive subjects and to ascertain its correlation with ASI and blood pressure.
Methodology: We studied a total of ninety male subjects ranging from 35-55 years of age. They were classified into normotensive, prehypertensive and hypertensive groups in light of JNC-8 Guidelines. Each group comprised of thirty subjects. Blood pressure was measured with mercury sphygmomanometer and digital volume pulse was recorded by photoplethysmography and ASI was calculated. Serum 8-isoprostane levels were measured by ELISA.
Results: Serum 8-isoprostane levels and ASI were significantly (0.0001) different amongst the three groups. The Post Hoc Tukey’s Test revealed p-value of 0.006 between normotensive and prehypertensive groups and 0.0001 between prehypertensive and hypertensive as well as normotensive and hypertensive groups for ASI. Plasma 8-isoprostane levels were non-significant (0.113) between normotensive and prehypertensive groups while significant (0.0001) between prehypertensive and hypertensive as well as normotensive and hypertensive groups. In normotensive subjects, the relationship between serum 8-isoprostane levels was moderately (r=0.4) correlated with ASI while, it was relatively strongly related with ASI in prehypertensive (r = 0.5) and hypertensive (r = 0.5) subjects.
Conclusion: The oxidative stress is involved in the development and worsening of arterial stiffness in prehypertensive and hypertensive patients.

Key words: Prehypertension, hypertension, arterial stiffness index, 8-isoprostane levels, oxidative stress.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Muhammad Sajid Mehmood
Articles by Muhammad Mazhar Hussain
Articles by Kamil Asghar Imam
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. 2018; 43(2): 349-353.

Web Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. https://www.rmj.org.pk/?mno=276688 [Access: August 15, 2023].

AMA (American Medical Association) Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. 2018; 43(2): 349-353.


Vancouver/ICMJE Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ. (2018), [cited August 15, 2023]; 43(2): 349-353.


Harvard Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam (2018) Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. RMJ, 43 (2), 349-353.


Turabian Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. 2018. Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. Rawal Medical Journal, 43 (2), 349-353.


Chicago Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. "Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects." Rawal Medical Journal 43 (2018), 349-353.


MLA (The Modern Language Association) Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam. "Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects." Rawal Medical Journal 43.2 (2018), 349-353. Print.


APA (American Psychological Association) Style

Muhammad Sajid Mehmood, Muhammad Mazhar Hussain, Kamil Asghar Imam (2018) Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects. Rawal Medical Journal, 43 (2), 349-353.


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information