Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study

Jelita Siregar; Hendri Wijaya; Raynald Pradigo; Marsha Santoso; Tedjo Sasmono; Inke Nadia Diniyanti Lubis

doi:10.5455/rmj.20251022040439

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RMJ. 2026; 51(1): 3-6

doi: 10.5455/rmj.20251022040439

Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study

Jelita Siregar, Hendri Wijaya, Raynald Pradigo, Marsha Santoso, Tedjo Sasmono, Inke Nadia Diniyanti Lubis.

Abstract
Objective: To compare diagnostic performance of SD Biosensor rapid diagnostic tests (RDT) (NS1, IgG, IgM) with other commercially employed RDTs.
Methodology: This cross-sectional study was conducted in two hospitals in Indonesia, enrolling 242 patients with suspected dengue. All patients were tested using both SD Biosensor RDT and alternative RDTs, with RT-PCR as the reference standard. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were assessed, and the groups were compared using the McNemar test.
Results: The SD Biosensor RDT exhibited higher sensitivity (65.2%) and NPV (74.5%), making it preferable for early detection. In contrast, alternative RDTs had higher specificity (96.9%) and PPV (90.6%), making them more effective for confirmatory diagnosis. McNemar analysis also showed a significant difference between the two tests.
Conclusion: The choice of RDT should be guided by clinical priorities. Enhancing RDT accuracy and addressing cross-reactivity remain critical for improving dengue diagnosis, particularly in resource-limited settings.

Key words: Rapid diagnostic test, biosensor, sensitivity, specificity, positive predictive value, negative predictive value.

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How to Cite this Article

Pubmed Style

Siregar J, Wijaya H, Pradigo R, Santoso M, Sasmono T, Lubis IND. Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. RMJ. 2026; 51(1): 3-6. doi:10.5455/rmj.20251022040439

Web Style

Siregar J, Wijaya H, Pradigo R, Santoso M, Sasmono T, Lubis IND. Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. https://www.rmj.org.pk/?mno=291951 [Access: February 21, 2026]. doi:10.5455/rmj.20251022040439

AMA (American Medical Association) Style

Siregar J, Wijaya H, Pradigo R, Santoso M, Sasmono T, Lubis IND. Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. RMJ. 2026; 51(1): 3-6. doi:10.5455/rmj.20251022040439

Vancouver/ICMJE Style

Siregar J, Wijaya H, Pradigo R, Santoso M, Sasmono T, Lubis IND. Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. RMJ. (2026), [cited February 21, 2026]; 51(1): 3-6. doi:10.5455/rmj.20251022040439

Harvard Style

Siregar, J., Wijaya, . H., Pradigo, . R., Santoso, . M., Sasmono, . T. & Lubis, . I. N. D. (2026) Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. RMJ, 51 (1), 3-6. doi:10.5455/rmj.20251022040439

Turabian Style

Siregar, Jelita, Hendri Wijaya, Raynald Pradigo, Marsha Santoso, Tedjo Sasmono, and Inke Nadia Diniyanti Lubis. 2026. Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study. Rawal Medical Journal, 51 (1), 3-6. doi:10.5455/rmj.20251022040439

Chicago Style

Siregar, Jelita, Hendri Wijaya, Raynald Pradigo, Marsha Santoso, Tedjo Sasmono, and Inke Nadia Diniyanti Lubis. "Diagnostic performance of dengue rapid diagnostic tests in Indonesia: A comparative study." Rawal Medical Journal 51 (2026), 3-6. doi:10.5455/rmj.20251022040439

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

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