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2026, Vol: 51, Issue: 3
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Case Report 


Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report

Rahmaidha Arofa Pradani, Ilham Wildan Ahmad, Alvin Hartanto Kurniawan, Jusak Nugraha, Eighty Mardiyan Kurniawati.


Abstract
Androgen Insensitivity Syndrome is a rare genetic condition characterized by the body's inability to respond to androgen hormones, leading to various phenotypic presentations, including amenorrhoea and vaginal agenesis. These disorders result from mutations of the androgen receptor gene. A 22-year-old woman with complaints of no menstruation since puberty. The patient was born and raised as a female.[L2.1][AK2.2] Physical examination revealed enlarged breasts, widened hips, female external genitalia, and no Adam's apple. Expressed sexual orientation was towards males. MRI imaging of the pelvis found abnormal signal, considered as cryptorchidism, no uterus or ovaries. Hormone examination showed estradiol 23.6 pg/mL, testosterone 88.67 mmol/L, LH 30.9 mIU/mL. Karyotyping revealed 46,XY. Histopa[L3.1][AK3.2]thological examination showed testicular tissue, surrounded by a connective tissue capsule. The patient gendered herself as female, neovaginal surgery and orchidectomy were performed. Disruption of this gene lead to a mismatch between phenotype and genotype. Therefore, comprehensive examinations are important.

Key words: Complete androgen insensitivity syndrome, 46,XY, testosterone, androgen receptor.


 
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How to Cite this Article
Pubmed Style

Pradani RA, Ahmad IW, Kurniawan AH, Nugraha J, Kurniawati EM. Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. RMJ. 2026; 51(3): 887-889. doi:10.5455/rmj.20260526041819

Web Style

Pradani RA, Ahmad IW, Kurniawan AH, Nugraha J, Kurniawati EM. Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. https://www.rmj.org.pk/?mno=322239 [Access: August 19, 2026]. doi:10.5455/rmj.20260526041819

AMA (American Medical Association) Style

Pradani RA, Ahmad IW, Kurniawan AH, Nugraha J, Kurniawati EM. Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. RMJ. 2026; 51(3): 887-889. doi:10.5455/rmj.20260526041819


Vancouver/ICMJE Style

Pradani RA, Ahmad IW, Kurniawan AH, Nugraha J, Kurniawati EM. Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. RMJ. (2026), [cited August 19, 2026]; 51(3): 887-889. doi:10.5455/rmj.20260526041819


Harvard Style

Pradani, R. A., Ahmad, . I. W., Kurniawan, . A. H., Nugraha, . J. & Kurniawati, . E. M. (2026) Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. RMJ, 51 (3), 887-889. doi:10.5455/rmj.20260526041819


Turabian Style

Pradani, Rahmaidha Arofa, Ilham Wildan Ahmad, Alvin Hartanto Kurniawan, Jusak Nugraha, and Eighty Mardiyan Kurniawati. 2026. Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. Rawal Medical Journal, 51 (3), 887-889. doi:10.5455/rmj.20260526041819


Chicago Style

Pradani, Rahmaidha Arofa, Ilham Wildan Ahmad, Alvin Hartanto Kurniawan, Jusak Nugraha, and Eighty Mardiyan Kurniawati. "Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report." Rawal Medical Journal 51 (2026), 887-889. doi:10.5455/rmj.20260526041819


MLA (The Modern Language Association) Style

Pradani, Rahmaidha Arofa, Ilham Wildan Ahmad, Alvin Hartanto Kurniawan, Jusak Nugraha, and Eighty Mardiyan Kurniawati. "Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report." Rawal Medical Journal 51.3 (2026), 887-889. Print. doi:10.5455/rmj.20260526041819


APA (American Psychological Association) Style

Pradani, R. A., Ahmad, . I. W., Kurniawan, . A. H., Nugraha, . J. & Kurniawati, . E. M. (2026) Complete androgen insensitivity syndrome in a 22-years-old woman with 46, XY chromosomes: A case report. Rawal Medical Journal, 51 (3), 887-889. doi:10.5455/rmj.20260526041819


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