Abstract
Objective: To determine the clinicopathological correlations of biopsy proven renal disease (BPRD) from a tertiary care naval hospital in Karachi, Pakistan.
Methods and patients: All the adequate native renal biopsies (RBs) in adult patients (≥18 years) performed at our hospital from 2008 to 2012 were retrospectively analyzed. The RBs were studied by light microscopy and immunofluorescence.
Results: A total 47 cases met the inclusion criteria of the study. The mean age was 33.23±12.11 years. Nephrotic syndrome (NS) was the most frequent indication, followed by renal failure (RF). Focal segmental glomerulosclerosis (FSGS) was the most common cause of NS, followed by membranous GN (MN), while chronic sclerosing GN was the most common cause of RF. The mean total number of glomeruli included in all RBs was 14.43±7.06. The mean number of gobally sclerosed glomeruli was 3.66±6.23 (range: 0-39) and the mean of segmentally sclerosed glomeruli, 0.94±1.55 (range: 0-7). Overall, global glomerulosclerosis (GS) was found in 31(66%) biopsies, and segmental glomerulosclerosis (SS) in 19 (40.4%) biopsies. Arteriolosclerosis (AS) was present in 12 (25.5%) of biopsies and hyaline arteriolosclerosis in 11(23.4%). Fibrointimal thickening of arteries was found in 13 (27.6%) cases. A variable degree of interstitial fibrosis and tubular atrophy (IFTA) was found in 41 (87.2%) cases and interstitial inflammation in 16 (34%) cases. Acute tubular necrosis (ATN) was found in 5 (10.6%) cases.
Conclusion:
This study provides the clinicopathological correlates of RBs in patients with medical renal diseases. Our data are more or less similar to those recently reported from around the world.

Key words: Glomerulonephritis, nephrotic syndrome, renal biopsy, renal failure.