Abstract
Objective: To study the incidence, risk factors and frequency of cholelithiasis and cholecystitis in the population of district Khairpur, Pakistan.
Methodology: A population based study was conducted in Department of Histopathology, PAQSJIMS, Gambat, Khairpur from January 2017 to August, 2018. A total of 56 cholecystectomy patients were included in the study. Post-surgery, gallbladder specimens were analyzed for histopathological spectrum after H&E stain. Microscopic observations were recorded.
Results: Out of 56 samples, 19.65% were from male whereas 80.35% from females. Chronic cholelithiasis (1.68%), chronic cholecystitis (22.96%), chronic cholecystitis with cholelithiasis (6.16%) and chronic ulcerated cholecystitis (0.56%) were the most common diagnoses. 16.07% of the male and 57.14% of female patients were found to be suffering from chronic cholecystitis. Age group 36 to 45 years was more prone to the gall bladder disease. Dyspepsia (92.85%) was the most common symptom. Focal ulceration and accumulation of acute and chronic inflammatory cells were observed both beneath the epithelium and subepithelium of the gallbladder.
Conclusion: The histopathological spectrum of gallbladder after cholecystectomy in district khairpur was observed to be quite diverse. The most dominant diagnosis was chronic cholecystitis followed by chronic cholecystitis with chronic cholelithiasis and chronic cholelithiasis whereas the chronic ulcerated cholecystitis was rarely observed.

Key words: : Gallstones, chronic cholecystitis, histopathology.