ISSN 0303-5212
 
2026, Vol: 51, Issue: 3
51 / 3Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_Certificate-old
Bank Reciept

Original Research 
RMJ. 2026; 51(3): 671-676


Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern

Sabhita Shabir Shaikh, Badder Hina Afnan, Shazia Siddiqui, Hafeez Ullah Shaikh, Saba Nafay.


Abstract
Objective: To compare the metabolic risk factors, anthropometric measures, biochemical parameters. dietary patterns and fibrosis scores (NFS and Fib-4) between males and females with MASLD.
Methodology: A total of 322 ultrasonography-confirmed MASLD patients were recruited in this observational study. Patients with advanced comorbidities, pregnancy, malignancies, or other causes of chronic liver diseases were excluded. Data on dietary intake, anthropometric measurements, and laboratory parameters were recorded. NFS and Fib-4 scores were calculated.
Results: Of 322 patients, 28.2% were males and 71.7% females. No significant difference was observed in fibrosis score, i.e., Fib-4 (p=0.28) or NFS (p=0.64) between males and females. However, males had significantly greater height, SGPT, ALP, GGT, and RBS (p<0.05) and decreased waist circumference as compared to females. In dietary patterns, males consumed more calorie-dense, processed foods (ice cream, pizza, chocolate, fried chicken/nuggets, juices, margarine) with significant associations (p<0.05), while females consumed more desi mithai (p=0.049).
Conclusion: No gender-based differences in fibrosis were observed among MASLD patients. However, males showed worse anthropometric and biochemical profiles alongside higher intake of unhealthy foods. These findings highlight the role of gender-specific factors in MASLD that lead to progression. Large randomized controlled trials are warranted to clarify sex-based differences in terms of occurrence and progression to fibrosis.

Key words: Dietary pattern, Metabolic Dysfunction-Associated Steatotic Liver, gender disparities, fibrosis.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sabhita Shabir Shaikh
Articles by Badder Hina Afnan
Articles by Shazia Siddiqui
Articles by Hafeez Ullah Shaikh
Articles by Saba Nafay
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Shaikh SS, Afnan BH, Siddiqui S, Shaikh HU, Nafay S. Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. RMJ. 2026; 51(3): 671-676.

Web Style

Shaikh SS, Afnan BH, Siddiqui S, Shaikh HU, Nafay S. Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. https://www.rmj.org.pk/?mno=283891 [Access: August 19, 2026].

AMA (American Medical Association) Style

Shaikh SS, Afnan BH, Siddiqui S, Shaikh HU, Nafay S. Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. RMJ. 2026; 51(3): 671-676.


Vancouver/ICMJE Style

Shaikh SS, Afnan BH, Siddiqui S, Shaikh HU, Nafay S. Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. RMJ. (2026), [cited August 19, 2026]; 51(3): 671-676.


Harvard Style

Shaikh, S. S., Afnan, . B. H., Siddiqui, . S., Shaikh, . H. U. & Nafay, . S. (2026) Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. RMJ, 51 (3), 671-676.


Turabian Style

Shaikh, Sabhita Shabir, Badder Hina Afnan, Shazia Siddiqui, Hafeez Ullah Shaikh, and Saba Nafay. 2026. Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. Rawal Medical Journal, 51 (3), 671-676.


Chicago Style

Shaikh, Sabhita Shabir, Badder Hina Afnan, Shazia Siddiqui, Hafeez Ullah Shaikh, and Saba Nafay. "Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern." Rawal Medical Journal 51 (2026), 671-676.


MLA (The Modern Language Association) Style

Shaikh, Sabhita Shabir, Badder Hina Afnan, Shazia Siddiqui, Hafeez Ullah Shaikh, and Saba Nafay. "Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern." Rawal Medical Journal 51.3 (2026), 671-676. Print.


APA (American Psychological Association) Style

Shaikh, S. S., Afnan, . B. H., Siddiqui, . S., Shaikh, . H. U. & Nafay, . S. (2026) Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern. Rawal Medical Journal, 51 (3), 671-676.


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information