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Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis

Durr e Sameen Kamran, Shahneela Siraj, Imran Ishaq, Sumaira Riffat, Aisha Abdul Haq, Afshan Mehboob Khan.

Abstract
Objective: To evaluate the diagnostic accuracy of peripheral smear morphology as a screening tool for Sickle cell trait/disease by comparing its results with hemoglobin electrophoresis.
Methodology: Two hundred persons of Sheedi/Makrani caste were included in the study during the period of one year from Lyari General Hospital, Karachi. Peripheral smears were prepared and electrophoresis was performed on their blood samples. Analysis was performed on SPSS16.
Results: Peripheral smear was found to be very sensitive and specific for Sickle cell disease, it was also found to be 100% specific for Sickle cell trait but it was not a very sensitive tool for Sickle trait screening.
Conclusion: CBC and smear morphology can be utilized for Sickle screening in high-risk areas, which can further be backed up by more sophisticated techniques in doubtful cases.

Key words: Complete Blood Count, hemoglobin electrophoresis, peripheral smear morphology, sickle cell trait, sickle cell disease.


 
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How to Cite this Article
Pubmed Style

Kamran DeS, Siraj S, Ishaq I, Riffat S, Haq AA, Khan AM. Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. RMJ. 2023; 48(1): 47-49.

Web Style

Kamran DeS, Siraj S, Ishaq I, Riffat S, Haq AA, Khan AM. Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. https://www.rmj.org.pk/?mno=29693 [Access: March 04, 2023].

AMA (American Medical Association) Style

Kamran DeS, Siraj S, Ishaq I, Riffat S, Haq AA, Khan AM. Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. RMJ. 2023; 48(1): 47-49.


Vancouver/ICMJE Style

Kamran DeS, Siraj S, Ishaq I, Riffat S, Haq AA, Khan AM. Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. RMJ. (2023), [cited March 04, 2023]; 48(1): 47-49.


Harvard Style

Kamran, D. e. S., Siraj, . S., Ishaq, . I., Riffat, . S., Haq, . A. A. & Khan, . A. M. (2023) Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. RMJ, 48 (1), 47-49.


Turabian Style

Kamran, Durr e Sameen, Shahneela Siraj, Imran Ishaq, Sumaira Riffat, Aisha Abdul Haq, and Afshan Mehboob Khan. 2023. Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. Rawal Medical Journal, 48 (1), 47-49.


Chicago Style

Kamran, Durr e Sameen, Shahneela Siraj, Imran Ishaq, Sumaira Riffat, Aisha Abdul Haq, and Afshan Mehboob Khan. "Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis." Rawal Medical Journal 48 (2023), 47-49.


MLA (The Modern Language Association) Style

Kamran, Durr e Sameen, Shahneela Siraj, Imran Ishaq, Sumaira Riffat, Aisha Abdul Haq, and Afshan Mehboob Khan. "Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis." Rawal Medical Journal 48.1 (2023), 47-49. Print.


APA (American Psychological Association) Style

Kamran, D. e. S., Siraj, . S., Ishaq, . I., Riffat, . S., Haq, . A. A. & Khan, . A. M. (2023) Validity of peripheral blood smear as a screening tool for Sickle Cell Anemia: Comparison with Electrophoresis. Rawal Medical Journal, 48 (1), 47-49.







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