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Original Research 
RMJ. 2024; 49(3): 656-660


Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice

Ghulam Mustafa Lodhi, Ayesha Shafqat, Beenish Zafar, Misbah Batool, Roomisa Anis, Azhar Ali Kazmi.


Abstract
Objective: To compare the effects of nigella sativa and pioglitazone on hyperglycemia, hyperlipidemia, adiponectin and resistin in streptozotocin induced diabetic mice.
Methodology: This quasi-experimental study was conducted from June 2021 to May 2022. Thirty mice were obtained. Fifteen were included in each of the two groups. Mice were given high fat diet for 8 weeks followed by low dose of streptozotocin injection intraperitoneally. After confirmation of diabetes, mice were enrolled for further study. Nigella sativa and pioglitazone in doses of 300 mg/kg and 30mg/kg were given by gavage tube once daily for 16 weeks. Blood glucose, adiponectin, resistin, cholesterol and triglycerides levels were observed after 16 weeks in both the groups. Statistical analyses were done by SPSS version 20.
Results: There were statistically significant changes in blood glucose, adiponectin, resistin, cholesterol and triglycerides levels in diabetic mice given pioglitazone as compared to those who received nigella sativa ethanolic extraction (p<0.001).
Conclusion: Pioglitazone significantly improved hyperglycemia, dyslipidemia, adiponectin and resistin in high fat diet, streptozotocin induced diabetic mice in comparison to nigella sativa ethanolic extraction.

Key words: Diabetes mellitus, adipokines, thiazolidinediones.


 
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How to Cite this Article
Pubmed Style

Lodhi GM, Shafqat A, Zafar B, Batool M, Anis R, Kazmi AA. Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. RMJ. 2024; 49(3): 656-660.

Web Style

Lodhi GM, Shafqat A, Zafar B, Batool M, Anis R, Kazmi AA. Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. https://www.rmj.org.pk/?mno=10065 [Access: September 12, 2024].

AMA (American Medical Association) Style

Lodhi GM, Shafqat A, Zafar B, Batool M, Anis R, Kazmi AA. Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. RMJ. 2024; 49(3): 656-660.


Vancouver/ICMJE Style

Lodhi GM, Shafqat A, Zafar B, Batool M, Anis R, Kazmi AA. Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. RMJ. (2024), [cited September 12, 2024]; 49(3): 656-660.


Harvard Style

Lodhi, G. M., Shafqat, . A., Zafar, . B., Batool, . M., Anis, . R. & Kazmi, . A. A. (2024) Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. RMJ, 49 (3), 656-660.


Turabian Style

Lodhi, Ghulam Mustafa, Ayesha Shafqat, Beenish Zafar, Misbah Batool, Roomisa Anis, and Azhar Ali Kazmi. 2024. Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. Rawal Medical Journal, 49 (3), 656-660.


Chicago Style

Lodhi, Ghulam Mustafa, Ayesha Shafqat, Beenish Zafar, Misbah Batool, Roomisa Anis, and Azhar Ali Kazmi. "Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice." Rawal Medical Journal 49 (2024), 656-660.


MLA (The Modern Language Association) Style

Lodhi, Ghulam Mustafa, Ayesha Shafqat, Beenish Zafar, Misbah Batool, Roomisa Anis, and Azhar Ali Kazmi. "Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice." Rawal Medical Journal 49.3 (2024), 656-660. Print.


APA (American Psychological Association) Style

Lodhi, G. M., Shafqat, . A., Zafar, . B., Batool, . M., Anis, . R. & Kazmi, . A. A. (2024) Comparison of nigella sativa and pioglitazone on hyperglycemia, adiponectin and resistin in streptozotocin induced diabetic mice. Rawal Medical Journal, 49 (3), 656-660.


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