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Original Research
Online Published: 09 Aug 2024
 
RMJ. 2024; 49(3): 669-672


Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar.


Abstract
Objective: To compare evading effects of alpha tocopherol, carvedilol, and metformin on early detection of myocardial damage caused by doxorubicin.
Methodology: This randomized in-vivo study in rabbits was performed from Oct 2021 to March 2022 at Department of Pharmacology & Therapeutics, Wah Medical College. A cohort of 30 healthy albino male adult rabbits were used. Cardiotoxicity was induced in one group by injecting doxorubicin whereas the control group was administered 0.9% saline. The pretreatment of the other three experimental groups was carried out with alpha tocopherol, carvedilol, and metformin for 11 days prior to doxorubicin injection. Blood sampling was taken on the 12th day for biomarkers and slides of heart sections were made for microscopic examination.
Results: Doxorubicin caused marked myocardial damage portrayed by elevation of serum biomarkers levels like cTnI, CK-MB and LDH, and severe necrosis of cardiac cells. Concurrent treatment with α-tocopherol, carvedilol and metformin led to reduced serum levels of these biomarkers with improved histopathological images, more obvious in carvedilol and metformin groups.
Conclusion: The use of carvedilol, metformin, and α-tocopherol can mitigate cardiac adverse effects doxorubicin. The quantitative estimation of serum cTnI may prove cost-effective by identifying extent of cardiac injury at subclinical stage.

Key words: Doxorubicin, cardiac troponin I, lactate dehydrogenase, LDH, creatine kinase-MB.


 
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How to Cite this Article
Pubmed Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . RMJ. 2024; 49(3): 669-672.

Web Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . https://www.rmj.org.pk/?mno=214971 [Access: September 12, 2024].

AMA (American Medical Association) Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . RMJ. 2024; 49(3): 669-672.


Vancouver/ICMJE Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . RMJ. (2024), [cited September 12, 2024]; 49(3): 669-672.


Harvard Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar (2024) Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . RMJ, 49 (3), 669-672.


Turabian Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. 2024. Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . Rawal Medical Journal, 49 (3), 669-672.


Chicago Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. "Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study ." Rawal Medical Journal 49 (2024), 669-672.


MLA (The Modern Language Association) Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar. "Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study ." Rawal Medical Journal 49.3 (2024), 669-672. Print.


APA (American Psychological Association) Style

Khalida Ajmal, Ayesha Afzal, Saima Rafique, Abbera Sikandar, Zahid Mahmood, Ayman Zafar (2024) Prevention of doxorubicin-associated cardiac toxicity by metformin, vitamin E, and carvedilol: A comparative study . Rawal Medical Journal, 49 (3), 669-672.


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