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Original Research 
RMJ. 2025; 50(3): 766-769


Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment

Gulshad Wagan, Pirya Nangdev, Sameena Gul Memon, Shamshad Bano, Kahaf Naz, Naveeta Rathi.


Abstract
Objective: To examine Catechins’ protective potential for neurodegeneration in autism-induced rats while exploring new findings about the Brain-derived neurotrophic factor (BDNF) in serum. Methodology: This experimental study was conducted at Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro from July 2019 to June 2020. A total of 25 Sprague-Dawley strain rats of healthy male gender aged seven weeks were used. These animals were distributed into five experimental groups based on Catechins doses by mouth for twenty-four days. The Primary Progressive Aphasia PPA+200 mg/kg Catechins treatment condition was used to induce the experimental group. We analysed BDNF level changes through ELISA method. The statistical evaluation employed ANOVA using the Post hoc Turkey test as the analysis method.
Results: We found that BDNF levels returned to normal levels within the groups who received Catechins treatment at III, IV, and V concentrations (compared to Group II), showing Catechins could potentially treat autism-like symptoms. The BDNF values measured in nano-grams per millilitre were Group I (13.1±0.3), followed by Group II (5.1±0.2) and Group III (9.8±0.3), Group IV (8.0±0.3), and then Group V (10.1±0.3). The BDNF concentration measured in Groups III, IV and V surpassed the BDNF level of Group II (PPA-induced) per results from a post-hoc Tukey's test at p<0.05 significance. Conclusion: The research found that Catechins treatment effectiveness against PPA-induced Autism Mouse models increased through elevated serum BDNF levels.

Key words: Catechins, BDNF, propionic acid (PPA), neurodegeneration, autism.


 
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How to Cite this Article
Pubmed Style

Wagan G, Nangdev P, Memon SG, Bano S, Naz K, Rathi N. Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. RMJ. 2025; 50(3): 766-769.

Web Style

Wagan G, Nangdev P, Memon SG, Bano S, Naz K, Rathi N. Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. https://www.rmj.org.pk/?mno=248560 [Access: October 30, 2025].

AMA (American Medical Association) Style

Wagan G, Nangdev P, Memon SG, Bano S, Naz K, Rathi N. Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. RMJ. 2025; 50(3): 766-769.


Vancouver/ICMJE Style

Wagan G, Nangdev P, Memon SG, Bano S, Naz K, Rathi N. Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. RMJ. (2025), [cited October 30, 2025]; 50(3): 766-769.


Harvard Style

Wagan, G., Nangdev, . P., Memon, . S. G., Bano, . S., Naz, . K. & Rathi, . N. (2025) Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. RMJ, 50 (3), 766-769.


Turabian Style

Wagan, Gulshad, Pirya Nangdev, Sameena Gul Memon, Shamshad Bano, Kahaf Naz, and Naveeta Rathi. 2025. Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. Rawal Medical Journal, 50 (3), 766-769.


Chicago Style

Wagan, Gulshad, Pirya Nangdev, Sameena Gul Memon, Shamshad Bano, Kahaf Naz, and Naveeta Rathi. "Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment." Rawal Medical Journal 50 (2025), 766-769.


MLA (The Modern Language Association) Style

Wagan, Gulshad, Pirya Nangdev, Sameena Gul Memon, Shamshad Bano, Kahaf Naz, and Naveeta Rathi. "Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment." Rawal Medical Journal 50.3 (2025), 766-769. Print.


APA (American Psychological Association) Style

Wagan, G., Nangdev, . P., Memon, . S. G., Bano, . S., Naz, . K. & Rathi, . N. (2025) Cross-linking catechins with neuro-regulatory model for autism spectrum disorder: A management in rats’ experiment. Rawal Medical Journal, 50 (3), 766-769.


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