Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy

Abeera Sikandar; Ayman Zafar; Khalida Ajmal; Ayesha Afzal; Noaman Ishaq; Jawaria Iftikhar

2025, Vol: 50, Issue: 4

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RMJ. 2025; 50(4): 915-918

Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy

Abeera Sikandar, Ayman Zafar, Khalida Ajmal, Ayesha Afzal, Noaman Ishaq, Jawaria Iftikhar.

Abstract
Objective: To compare the sedative and anxiolytic effects of intravenous dexmedetomidine, oral pregabalin and alprazolam as a standard drug for sedation/anxiety in patients undergoing laparoscopic cholecystectomy.
Methodology: This randomized, double-blind, controlled trial included 96 ASA I and II patients aged 18–60 years scheduled for elective laparoscopic cholecystectomy. Patients were randomly allocated into three equal groups (32 in each group). Group 1 received IV dexmedetomidine (1 µg/kg) 10 min before induction, Group 2 received oral pregabalin (300 mg), and Group 3 received oral alprazolam (0.5 mg) 90 min before induction. Sedation was assessed using the modified Ramsay Sedation Scale and anxiety using the Beck Anxiety Inventory at baseline and before induction. Statistical analysis was performed using SPSS 25; p≤0.05 was considered significant.
Results: All three groups showed significant improvement in sedation and anxiety scores from baseline. Dexmedetomidine produced significantly higher sedation (p<0.001) and anxiolysis (p=0.006) compared to pregabalin (p=0.004; p=0.025) and alprazolam (p=0.012; p=0.003).
Conclusion: Dexmedetomidine demonstrated superior sedative and anxiolytic efficacy compared to pregabalin and alprazolam in patients undergoing laparoscopic cholecystectomy.

Key words: Alprazolam; Dexmedetomidine; General Anesthesia; Laparoscopic Cholecystectomy; Pregabalin; Premedication

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Pubmed Style

Sikandar A, Zafar A, Ajmal K, Afzal A, Ishaq N, Iftikhar J. Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy. RMJ. 2025; 50(4): 915-918.

Web Style

Sikandar A, Zafar A, Ajmal K, Afzal A, Ishaq N, Iftikhar J. Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy. https://www.rmj.org.pk/?mno=258168 [Access: October 30, 2025].

AMA (American Medical Association) Style

Sikandar A, Zafar A, Ajmal K, Afzal A, Ishaq N, Iftikhar J. Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy. RMJ. 2025; 50(4): 915-918.

Vancouver/ICMJE Style

Harvard Style

Sikandar, A., Zafar, . A., Ajmal, . K., Afzal, . A., Ishaq, . N. & Iftikhar, . J. (2025) Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy. RMJ, 50 (4), 915-918.

Turabian Style

Sikandar, Abeera, Ayman Zafar, Khalida Ajmal, Ayesha Afzal, Noaman Ishaq, and Jawaria Iftikhar. 2025. Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy. Rawal Medical Journal, 50 (4), 915-918.

Chicago Style

Sikandar, Abeera, Ayman Zafar, Khalida Ajmal, Ayesha Afzal, Noaman Ishaq, and Jawaria Iftikhar. "Evaluation and comparison of the sedative and anxiolytic effects of Dexmedetomidine and Pregabalin with Alprazolam in patients undergoing laparoscopic cholecystectomy." Rawal Medical Journal 50 (2025), 915-918.

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