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Case Report 
RMJ. 2017; 42(4): 587-589


Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.

Anna Misya'il Abdul Rashid, Mohamad Syafeeq Faeez Md Noh, Fan Kee Hoo, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, Hamidon Basri.


Abstract
Creutzfeldt-Jakob disease (CJD) is a rare disorder that presents with a myriad of symptoms. Early features may include pyramidal and cerebellar signs with very vague history of dementia. This makes diagnosis particularly challenging; especially when a different diagnosis is more common. Unavailability of laboratory testing in most centers also limits the diagnosis. Newer literature agrees on the reliability of neuroimaging, namely magnetic resonance imaging (MRI) and its role in providing a clear diagnosis in CJD. We report a patient presenting with dementia, pyramidal symptoms and later had myoclonic jerks. He refused lumbar puncture, and electroencephalogram (EEG) changes were not typical of CJD. Only on MRI were we able to prove his diagnosis as workup for alternative diagnoses were negative. Though there is no curative intervention, supportive treatment proves of utmost importance during the course of illness.

Key words: Creutzfeldt-Jakob disease, dementia, pyramidal signs, lumbar puncture, electroencephalogram (EEG), magnetic resonance imaging (MRI).


 
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How to Cite this Article
Pubmed Style

Rashid AMA, Noh MSFM, Hoo FK, Sulaiman WAW, Mat LNI, Basri H. Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. RMJ. 2017; 42(4): 587-589.

Web Style

Rashid AMA, Noh MSFM, Hoo FK, Sulaiman WAW, Mat LNI, Basri H. Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. https://www.rmj.org.pk/?mno=258700 [Access: October 30, 2025].

AMA (American Medical Association) Style

Rashid AMA, Noh MSFM, Hoo FK, Sulaiman WAW, Mat LNI, Basri H. Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. RMJ. 2017; 42(4): 587-589.


Vancouver/ICMJE Style

Rashid AMA, Noh MSFM, Hoo FK, Sulaiman WAW, Mat LNI, Basri H. Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. RMJ. (2017), [cited October 30, 2025]; 42(4): 587-589.


Harvard Style

Rashid, A. M. A., Noh, . M. S. F. M., Hoo, . F. K., Sulaiman, . W. A. W., Mat, . L. N. I. & Basri, . H. (2017) Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. RMJ, 42 (4), 587-589.


Turabian Style

Rashid, Anna Misyail Abdul, Mohamad Syafeeq Faeez Md Noh, Fan Kee Hoo, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, and Hamidon Basri. 2017. Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. Rawal Medical Journal, 42 (4), 587-589.


Chicago Style

Rashid, Anna Misyail Abdul, Mohamad Syafeeq Faeez Md Noh, Fan Kee Hoo, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, and Hamidon Basri. "Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.." Rawal Medical Journal 42 (2017), 587-589.


MLA (The Modern Language Association) Style

Rashid, Anna Misyail Abdul, Mohamad Syafeeq Faeez Md Noh, Fan Kee Hoo, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, and Hamidon Basri. "Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.." Rawal Medical Journal 42.4 (2017), 587-589. Print.


APA (American Psychological Association) Style

Rashid, A. M. A., Noh, . M. S. F. M., Hoo, . F. K., Sulaiman, . W. A. W., Mat, . L. N. I. & Basri, . H. (2017) Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge.. Rawal Medical Journal, 42 (4), 587-589.


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