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2025, Vol: 50, Issue: 4
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Original Research 
RMJ. 2025; 50(3): 759-761


True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential

Pashmina Shaikh, Umbreen Bano, Muryyum Dilshad, Sehar Khowaja, Asim Mehmood, Sameena Gul Memon.


Abstract
Objective: To design an in vivo care model via anthocyanins’ neuro-protective therapeutic potential.
Methodology: In this vivo experiment, 20 healthy male eight weeks old rats were selected, and five groups were formed. Group I was the physiological/non-induced rats, where four other groups (n=16) of various sizes were administered with intraperitoneal injections of propionic acid (250 mg/kg/day for 5 days). Group II (induced with propionic acid PPA), Groups III, IV, and V used anthocyanin at the concentrations of 100 mg/kg, 200 mg/kg, and 400 mg/kg, respectively a regular diet for a total of 4 weeks. ELISA detected neurotrophins levels with Statistical analysis of ANOVA (Post hoc Turkey test).
Results: The levels of brain-derived neurotrophic factor (BDNF) were observed in the Anthocyanin-treated groups (III, IV, and V) as compared with the group (II), inferring that Anthocyanin therapy can heal autism like symptoms. The levels of measured BDNF (ng/ml) were as follows: Group I (12.1 ± 0.5), II (4.1 ±0.5), III (9.1 ±0.5), IV (7.5 ±0.5), and V (9.7 ±0.5). To be specific, BDNF levels in Groups III, IV, and V were higher than in Group II (PPA-induced) (p<0.05).
Conclusion: Anthocyanin was found to interact with PPA-induced Autism Mouse models proportional to the recovery in serum BNDF levels.

Key words: Anthocyanin, neurodegeneration, autism models.


 
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How to Cite this Article
Pubmed Style

Shaikh P, Bano U, Dilshad M, Khowaja S, Mehmood A, Memon SG. True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. RMJ. 2025; 50(3): 759-761.

Web Style

Shaikh P, Bano U, Dilshad M, Khowaja S, Mehmood A, Memon SG. True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. https://www.rmj.org.pk/?mno=248564 [Access: October 30, 2025].

AMA (American Medical Association) Style

Shaikh P, Bano U, Dilshad M, Khowaja S, Mehmood A, Memon SG. True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. RMJ. 2025; 50(3): 759-761.


Vancouver/ICMJE Style

Shaikh P, Bano U, Dilshad M, Khowaja S, Mehmood A, Memon SG. True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. RMJ. (2025), [cited October 30, 2025]; 50(3): 759-761.


Harvard Style

Shaikh, P., Bano, . U., Dilshad, . M., Khowaja, . S., Mehmood, . A. & Memon, . S. G. (2025) True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. RMJ, 50 (3), 759-761.


Turabian Style

Shaikh, Pashmina, Umbreen Bano, Muryyum Dilshad, Sehar Khowaja, Asim Mehmood, and Sameena Gul Memon. 2025. True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. Rawal Medical Journal, 50 (3), 759-761.


Chicago Style

Shaikh, Pashmina, Umbreen Bano, Muryyum Dilshad, Sehar Khowaja, Asim Mehmood, and Sameena Gul Memon. "True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential." Rawal Medical Journal 50 (2025), 759-761.


MLA (The Modern Language Association) Style

Shaikh, Pashmina, Umbreen Bano, Muryyum Dilshad, Sehar Khowaja, Asim Mehmood, and Sameena Gul Memon. "True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential." Rawal Medical Journal 50.3 (2025), 759-761. Print.


APA (American Psychological Association) Style

Shaikh, P., Bano, . U., Dilshad, . M., Khowaja, . S., Mehmood, . A. & Memon, . S. G. (2025) True experimental insights: Designing in-vivo care model via anthocyanins’ neuroprotective therapeutic potential. Rawal Medical Journal, 50 (3), 759-761.


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