ISSN 0303-5212
 
2026, Vol: 51, Issue: 2
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Original Research 


Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study

Yohanna Fransisca Sinuhaji, Taufik Sungkar, Ilhamd Ilhamd.


Abstract
Objective: To evaluate the association between the Albumin–Bilirubin (ALBI) score and mortality risk in patients with hepatocellular carcinoma (HCC).
Methodology: This retrospective cohort study was conducted at Haji Adam Malik General Hospital, Medan, Indonesia, from September 2024 to April 2025. Medical records of adult patients with HCC and complete clinical and laboratory data were analysed. ALBI scores were categorized into three grades. Associations with mortality were evaluated using the chi-square test and Mann–Whitney U test.
Results: A total of 135 patients were included. Higher ALBI grades were significantly associated with increased mortality (p<0.05). Patients with ALBI grade III had lower serum albumin levels and higher total bilirubin levels than those with ALBI grades I and II. Mortality was highest among patients with Child–Pugh class C and BCLC stage D.
Conclusion: The ALBI score is a simple and objective prognostic tool for predicting mortality in patients with HCC and may complement established prognostic systems such as the Child–Pugh and BCLC classifications.

Key words: Albumin–Bilirubin score, hepatocellular carcinoma, liver function, mortality, prognosis.


 
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How to Cite this Article
Pubmed Style

Sinuhaji YF, Sungkar T, Ilhamd I. Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. RMJ. 2026; 51(2): 326-330. doi:10.5455/rmj.20251030044431

Web Style

Sinuhaji YF, Sungkar T, Ilhamd I. Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. https://www.rmj.org.pk/?mno=293476 [Access: May 26, 2026]. doi:10.5455/rmj.20251030044431

AMA (American Medical Association) Style

Sinuhaji YF, Sungkar T, Ilhamd I. Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. RMJ. 2026; 51(2): 326-330. doi:10.5455/rmj.20251030044431


Vancouver/ICMJE Style

Sinuhaji YF, Sungkar T, Ilhamd I. Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. RMJ. (2026), [cited May 26, 2026]; 51(2): 326-330. doi:10.5455/rmj.20251030044431


Harvard Style

Sinuhaji, Y. F., Sungkar, . T. & Ilhamd, . I. (2026) Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. RMJ, 51 (2), 326-330. doi:10.5455/rmj.20251030044431


Turabian Style

Sinuhaji, Yohanna Fransisca, Taufik Sungkar, and Ilhamd Ilhamd. 2026. Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. Rawal Medical Journal, 51 (2), 326-330. doi:10.5455/rmj.20251030044431


Chicago Style

Sinuhaji, Yohanna Fransisca, Taufik Sungkar, and Ilhamd Ilhamd. "Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study." Rawal Medical Journal 51 (2026), 326-330. doi:10.5455/rmj.20251030044431


MLA (The Modern Language Association) Style

Sinuhaji, Yohanna Fransisca, Taufik Sungkar, and Ilhamd Ilhamd. "Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study." Rawal Medical Journal 51.2 (2026), 326-330. Print. doi:10.5455/rmj.20251030044431


APA (American Psychological Association) Style

Sinuhaji, Y. F., Sungkar, . T. & Ilhamd, . I. (2026) Association between the Albumin-Bilirubin Score and mortality risk in patients with hepatocellular carcinoma: A retrospective cohort study. Rawal Medical Journal, 51 (2), 326-330. doi:10.5455/rmj.20251030044431


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